Saudi Journal of Kidney Diseases and Transplantation

: 2009  |  Volume : 20  |  Issue : 6  |  Page : 1083--1084

Calcific uremic arteriopathy

Pranav Dalal, Gaurav Shah 
 Mount Sinai Hospital, (Chicago Medical School), Department of Internal Medicine, Chicago, Il 60612, USA

Correspondence Address:
Pranav Dalal
Mount Sinai Hospital, (Chicago Medical School), Department of Internal Medicine, Chicago, Il 60612

How to cite this article:
Dalal P, Shah G. Calcific uremic arteriopathy.Saudi J Kidney Dis Transpl 2009;20:1083-1084

How to cite this URL:
Dalal P, Shah G. Calcific uremic arteriopathy. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2020 Aug 6 ];20:1083-1084
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Full Text

To the Editor,

58-year-old female with diabetes mellitus and end stage renal disease was admitted to the hospital for shortness of breath after missing hemodialysis. Patient had fall during the hos­pitalization and X-rays of wrist were taken to rule out any fracture or dislocation. The radio­graphs did not show any fracture or dislocation but showed severe calcification of radial and ulnar arteries as well as small arteries of hand, [Figure 1] and [Figure 2] Patient had no evidence of vascular insufficiency or gangrene of digits. Calcific Uremic Arteriopathy also known as "calciphylaxis" is a syndrome of arterial calci­fication and tissue necrosis that occurs in 1-4% of patient with chronic kidney disease on long­term treatment with dialysis. [1],[2] Although patho­genesis is unclear, it is usually associated with high Calcium-Phosphate product level and hy­perparathyroidism. [3] It can lead to skin necrosis and infection which is difficult to treat. Con­trolling Calcium level with bisphosphonates, phosphate binders and low calcium dialysis bath can be helpful preventing progression of condition. Despite, aggressive treatment mor­tality ranges between 60-80%. [4]


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2Coates T, Kirkland GS, Dymock RB, et al. Cu­taneous necrosis from calcific uremic arterio­lopathy. Am J Kidney Dis 1998;32(3):384-91.
3Wilmer WA, Magro CM. Calciphylaxis: emer­ging concepts in prevention, diagnosis, and treatment. Semin Dial 2002;15(3):172-86.
4Bardsley S, Coutts R, Wilson C. Calciphylaxis and its surgical significance. ANZ J Surg 2005;75(5):356-9.