Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2011  |  Volume : 22  |  Issue : 6  |  Page : 1219--1222

Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis


Bassam Saeed, Houda Mazloum, Munaf Askar 
 Pediatric Nephrology Department, Kidney Hospital, Damascus, Syria

Correspondence Address:
Bassam Saeed
Pediatric Nephrology Department, Kidney Hospital, P.O. Box 8292, Damascus
Syria

A 12-year-old girl with a history of steroid and cyclosporine (CsA) resistant nephrotic syndrome owing to focal and segmental glomerulosclerosis (FSGS) has progressed to end-stage renal disease (ESRD) for which she underwent hemodialysis for 18 months before she successfully received a fully matched kidney transplant from her sister at the age of nine years. The post transplantation (Tx) period was marked by an early and massive proteinuria indicating recurrent FSGS for which she received 12 sessions of plasmapheresis (PP); unfortunately, she did not appear to have any response to the PP therapy; thereafter, a conservative management comprising essentially enalapril and losartan has been initiated and was also not successful during the first four months, however, a very gradual response has been noticed to occur after five months of conservative therapy and ultimately, the patient attained complete remission after 21 months of treatment. Amazingly, 15 months after discontinuation of enalapril and losartan, she remained in a complete and sustained remission with a good renal allograft function. To the best of our knowledge, this is the first case ever reported in the literature of a «DQ»spontaneous«DQ» remission of post transplant recurrent FSGS.


How to cite this article:
Saeed B, Mazloum H, Askar M. Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis.Saudi J Kidney Dis Transpl 2011;22:1219-1222


How to cite this URL:
Saeed B, Mazloum H, Askar M. Spontaneous remission of post-transplant recurrent focal and segmental glomerulosclerosis. Saudi J Kidney Dis Transpl [serial online] 2011 [cited 2020 Feb 25 ];22:1219-1222
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=6;spage=1219;epage=1222;aulast=Saeed;type=0