Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2013  |  Volume : 24  |  Issue : 4  |  Page : 764--767

Esophageal histoplasmosis in a renal allograft recipient


LC Sharma1, J Falodia1, K Kalla2, M Kalla3, JB Gupta4, SS Gupta1, P Beniwal1, MN Singh1, V Malhotra1, D Agarwal1 
1 Department of Nephrology, SMS Hospital and Medical College, Jaipur, India
2 Department of Pathology, S. R. Kalla Memorial Gastro and General Hospital, Jaipur, India
3 Department of Gastroenterology, S. R. Kalla Memorial Gastro and General Hospital, Jaipur, India
4 Department of Nephrology, S. R. Kalla Memorial Gastro and General Hospital, Jaipur, India

Correspondence Address:
S S Gupta
Department of Nephrology, SMS Medical College and Hospital, Jaipur - 302 004
India

Histoplasmosis is a progressive granulomatous disease caused by the intracellular dimorphic fungus Histoplasma capsulatum. We report a rare case of esophageal histoplasmosis in a renal allograft recipient. A 55-year-old male who received a live, unrelated renal allograft 20 years ago presented with complaints of recurrent fever for ten to 12 months, weight loss over six months, progressive dysphagia more for solids for five to six months and joint pain and swelling involving the bilateral metacarpo-phalangeal and proximal interphalangeal joints. Biopsy from the esophageal ulcers revealed dense inflammation infiltrated with lymphocytes and macrophages with clusters of strongly positive intracellular fungal spores with a clear area or DQhalo-likeDQ zone suggestive of Histoplasma capsulatum invasion. The patient was treated with intravenous liposomal amphotericin B for ten days and later switched over to oral itraconazole. Repeated endoscopy revealed significant improvement of the lesions.


How to cite this article:
Sharma L C, Falodia J, Kalla K, Kalla M, Gupta J B, Gupta S S, Beniwal P, Singh M N, Malhotra V, Agarwal D. Esophageal histoplasmosis in a renal allograft recipient.Saudi J Kidney Dis Transpl 2013;24:764-767


How to cite this URL:
Sharma L C, Falodia J, Kalla K, Kalla M, Gupta J B, Gupta S S, Beniwal P, Singh M N, Malhotra V, Agarwal D. Esophageal histoplasmosis in a renal allograft recipient. Saudi J Kidney Dis Transpl [serial online] 2013 [cited 2020 Jul 13 ];24:764-767
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2013;volume=24;issue=4;spage=764;epage=767;aulast=Sharma;type=0