Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 26  |  Issue : 4  |  Page : 712--717

Serum cystatin-C and BETA 2-microglobulin as accurate markers in the early diagnosis of kidney injury in neonates: A single center study


Mohamed S El-Frargy1, Ahmed M El-Refaey2, Riham Eid2, Mokhtar A Hussien2 
1 Department of Pediatric, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Pediatric Nephrology Unit, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt

Correspondence Address:
Ahmed M El-Refaey
Pediatric Nephrology Unit, Mansoura University Children«SQ»s Hospital, Mansoura University, Mansoura
Egypt

Early detection of kidney injury in neonates is very important for appropriate management and prevention of serious complications; however, commonly used detectors as creatinine and blood urea nitrogen (BUN) do not directly reflect early renal cell injury. Serum cystatin-C (Cys-C) and beta 2-microglobulin (Β2M), serum creatinine and BUN were assessed in 20 neonates who developed renal impairment after admission to the neonatal intensive care unit and 10 healthy neonates. The means of serum Cys-C, Β2M and creatinine on Day 1 of admission in the cases and control groups were 2.15 ± 0.52 vs 0.45 ± 0.19, 7.18 ± 2.36 vs 1.92 ± 0.41 and 0.81 ± 0.07 vs 0.53 ± 0.20, respectively, with P-value <0.05 in only Cys-C and Β2M. We conclude that serum Cys-C and Β2M are suggested as simple and accurate markers for the early diagnosis of kidney injury in neonates than serum creatinine.


How to cite this article:
El-Frargy MS, El-Refaey AM, Eid R, Hussien MA. Serum cystatin-C and BETA 2-microglobulin as accurate markers in the early diagnosis of kidney injury in neonates: A single center study.Saudi J Kidney Dis Transpl 2015;26:712-717


How to cite this URL:
El-Frargy MS, El-Refaey AM, Eid R, Hussien MA. Serum cystatin-C and BETA 2-microglobulin as accurate markers in the early diagnosis of kidney injury in neonates: A single center study. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2020 Jul 13 ];26:712-717
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=4;spage=712;epage=717;aulast=El-Frargy;type=0