Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2016  |  Volume : 27  |  Issue : 1  |  Page : 153--156

Malignant hypertension-associated thrombotic microangiopathy following cocaine use


Rais Lamia1, Zohra El Ati1, Lilia Ben Fatma1, Karim Zouaghi1, Wided Smaoui1, Khedher Rania1, Madiha Krid1, Fathi Ben Hmida2, Soumaya Béji1, Fatma Ben Moussa1 
1 Nephrology Department, La Rabta Hospital, Tunis, Tunisia
2 Laboratory of Renal Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia

Correspondence Address:
Rais Lamia
Nephrology Department, La Rabta Hospital, Jabbari, 1007, Tunis
Tunisia

Cocaine is one of the most commonly used illicit drugs with distribution and consumption throughout the world. Acute renal failure associated with rhabdomyolysis, direct vasoconstriction and hemodynamic alteration is well described in patients with cocaine intoxication. Cocaine use is associated with high blood pressure and may rarely induce malignant hypertension associated with thrombotic microangiopathy. We report the case of a patient who developed malignant hypertension associated with thrombotic microangiopathy after chronic consumption of cocaine. A kidney biopsy revealed thrombotic microangiopathy with fibrinoid necrosis of arterioles and glomerular tufts. He required dialysis sessions. Cocaine-mediated endothelial injury and platelet activation may play important pathogenetic roles in cocaine abusers who develop malignant hypertension associated with thrombotic microangiopathy. Clinicians need to be aware of this rare feature of cocaine intoxication.


How to cite this article:
Lamia R, El Ati Z, Fatma LB, Zouaghi K, Smaoui W, Rania K, Krid M, Hmida FB, Béji S, Moussa FB. Malignant hypertension-associated thrombotic microangiopathy following cocaine use.Saudi J Kidney Dis Transpl 2016;27:153-156


How to cite this URL:
Lamia R, El Ati Z, Fatma LB, Zouaghi K, Smaoui W, Rania K, Krid M, Hmida FB, Béji S, Moussa FB. Malignant hypertension-associated thrombotic microangiopathy following cocaine use. Saudi J Kidney Dis Transpl [serial online] 2016 [cited 2020 Jul 13 ];27:153-156
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=1;spage=153;epage=156;aulast=Lamia;type=0