Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 27  |  Issue : 2  |  Page : 312--319

Utility of saliva as a sample to assess renal function and estimated glomerular filtration rate


Naresh Yajamanam1, Kiranmayi S Vinapamula1, V Sivakumar2, Aparna R Bitla1, P. V. L. N. Srinivasa Rao1 
1 Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
2 Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Correspondence Address:
P. V. L. N. Srinivasa Rao
Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh - 517 507
India

Diagnosis of renal diseases by assessing renal parameters in saliva. Biochemical investigations using serum form important component of monitoring patients with renal disease. Utility of saliva, in diagnosis and monitoring of patients with renal disease and for calculation of estimated glomerular filtration rate (eGFR), was studied. Sixty patients with renal disease and sixty ageand sex-matched healthy controls were studied. Urea, creatinine, sodium, potassium, uric acid, calcium, and phosphorus were measured in both serum and saliva. eGFR was calculated using salivary creatinine. Data were expressed as mean ± standard deviation. Comparison and correlation between groups were assessed by Student«SQ»s t-test and Pearson correlation, respectively. Bland-Altman plot, mountain plot, and intra-class correlation coefficient were used to test agreement. A P <0.05 was considered statistically significant. Statistical analysis was done using Microsoft excel spreadsheets, Medcalc Version 10.0, and SPSS version 11.5. Salivary levels of urea, creatinine, uric acid, sodium, potassium, and phosphorus were higher in patients compared to controls. Potassium and phosphorus levels were higher (P = 0.001) and creatinine, sodium, calcium, and uric acid levels were lower (P = 0.001) in saliva compared to serum in both patients and controls. Positive correlation was observed between serum and salivary urea and creatinine (P < 0.0001). eGFR values calculated from salivary creatinine showed good agreement with those calculated form serum creatinine. Salivary urea (>6 mmol/L) and creatinine (>14.6 μmol/L) and eGFR calculated from salivary creatinine can be used to identify patients with renal disease.


How to cite this article:
Yajamanam N, Vinapamula KS, Sivakumar V, Bitla AR, Rao PS. Utility of saliva as a sample to assess renal function and estimated glomerular filtration rate.Saudi J Kidney Dis Transpl 2016;27:312-319


How to cite this URL:
Yajamanam N, Vinapamula KS, Sivakumar V, Bitla AR, Rao PS. Utility of saliva as a sample to assess renal function and estimated glomerular filtration rate. Saudi J Kidney Dis Transpl [serial online] 2016 [cited 2020 Feb 25 ];27:312-319
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=312;epage=319;aulast=Yajamanam;type=0