Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 27  |  Issue : 6  |  Page : 1194--1199

Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients


Yosra Guedri1, K Najla Damma1, Melek Toumi2, Wissal Sahtout1, Awatef Azzabi1, Sinda Mrabet1, Safa Nouira1, Dalila Saidane2, Samira Amor1, Anis Belarbia1, Dorsaf Zellama1, Abdellatif Achour1 
1 Department of Nephrology, Dialysis and Transplantation, Sahloul Hospital, Sousse, Tunisia
2 Faculty of Pharmacy, Monastir, Tunisia

Correspondence Address:
Yosra Guedri
Department of Nephrology, Dialysis and Transplantation, Sahloul Hospital, Sousse
Tunisia

Peritoneal protein loss is one of the inevitable consequences during continuous ambulatory peritoneal dialysis (CAPD). Our objective was to study the effect of sulodexide on the protein loss and efficiency of dialysis. This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days. Clinical and biologic parameters were assessed before starting the treatment (D0 and after 10 days of treatment (D10. We also evaluated the benefit of therapy persisting 20 days after the end of treatment (D30. The sulodexide administration produced a significant improvement of the peritoneal function as determined by a significant increase in the following ratios measured at the 4 th h of dwell time on D0 and D30: dialysate-to plasma (D/P) creatinine from 0.63 ± 1.45 to 0.85 ± 0.073 (P = 0.028) and D/P urea from 0.63 ± 0.15 to 79 ± 0.2 (P = 0.048). A significant decrease of albumin leakage was observed, which was 0.90 ± 0.40 g/L at baseline, 0.67 ± 0.36 g/L on the 10 th day, and 0.43 ± 0.22g/L 20 days after the end of treatment. Within 10-day treatment period, use of sulodexide resulted in a reduction in the peritoneal loss of albumin, in addition to improvement of the quality of dialysis and the residual renal function among these patients.


How to cite this article:
Guedri Y, Damma K N, Toumi M, Sahtout W, Azzabi A, Mrabet S, Nouira S, Saidane D, Amor S, Belarbia A, Zellama D, Achour A. Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients.Saudi J Kidney Dis Transpl 2016;27:1194-1199


How to cite this URL:
Guedri Y, Damma K N, Toumi M, Sahtout W, Azzabi A, Mrabet S, Nouira S, Saidane D, Amor S, Belarbia A, Zellama D, Achour A. Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients. Saudi J Kidney Dis Transpl [serial online] 2016 [cited 2020 Feb 23 ];27:1194-1199
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=6;spage=1194;epage=1199;aulast=Guedri;type=0