Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 28  |  Issue : 3  |  Page : 532--537

Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia


Turki Al-Hussain, Shuaa Asiri, Sadiq Amer, Hadeel Al Mana, Mohammed Akhtar 
 Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Turki Al-Hussain
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, MBC-10, P. O. Box 3354, Riyadh 11211
Kingdom of Saudi Arabia

A series of 78 cases of glomerulonephritis (GN), in which renal biopsy revealed changes of GN associated with crescent formation, were reviewed. Renal pathology findings were correlated with clinical features including patient’s age, renal function, and serologic findings. In most of the cases (71.8%), the crescents were due to immune complex-mediated GN. This was followed by pauci-immune GN (20.5%) and anti-glomerular basement membrane antibody (GBM) GN (7.7%). The percentage of glomeruli with crescents was the highest in cases of anti-GBM disease (mean of 93.3%), followed by pauci-immune GBM (mean of 48.2%) and immune complex GN (30.9%). In cases with the pauci- immune GN, there were additional features of glomerular injury including fibrinoid necrosis, disruption of the GBM, and rupture of Bowman’s capsule. These changes were generally more pronounced in a subset of pauci-immune GN associated with serum elevation of antineutrophil cytoplasmic antibody (c-ANCA). In biopsies from patient with immune complex disease, systemic lupus erythematosus was the most common cause of crescentic GN.


How to cite this article:
Al-Hussain T, Asiri S, Amer S, Al Mana H, Akhtar M. Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia.Saudi J Kidney Dis Transpl 2017;28:532-537


How to cite this URL:
Al-Hussain T, Asiri S, Amer S, Al Mana H, Akhtar M. Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2020 Jul 3 ];28:532-537
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=3;spage=532;epage=537;aulast=Al-Hussain;type=0