Saudi Journal of Kidney Diseases and Transplantation

: 2017  |  Volume : 28  |  Issue : 3  |  Page : 664--665

The role of hypercalciuria in pathogenesis of recurrent abdominal pain

Majid Malaki 
 Pediatric Nephrology Ward, Sevom-e-Shaban Hospital, Tehran, Iran

Correspondence Address:
Dr. Majid Malaki
Pediatric Nephrology Ward, Sevom-e-Shaban Hospital, Tehran

How to cite this article:
Malaki M. The role of hypercalciuria in pathogenesis of recurrent abdominal pain.Saudi J Kidney Dis Transpl 2017;28:664-665

How to cite this URL:
Malaki M. The role of hypercalciuria in pathogenesis of recurrent abdominal pain. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2020 Jul 13 ];28:664-665
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Full Text

To the Editor,

More than 100 different conditions may cause recurrent abdominal pain in children but it is almost always attributed to functional disorders.[1] Hypercalciuria is a well-known cause for chronic and recurrent abdominal pain (RAP).[2] Polito et al were not able to find increased incidence of recurrent abdominal pain in children with a history of urolithiasis.[1]

This cross-sectional study tries to find the prevalence of hypercalciuria (random urine calcium to creatinine >0.21) and urolithiasis in 46 children aged over three years with a complaint of chronic abdominal pain for more than two months recurrent abdominal pain. A group and 37 normal age-matched cases selected randomly as control group.

The mean age of the study group was 5.96 ± 2; 52% of whom were female and 48% were male. Kidney ultrasound showed kidney stones or other renal abnormalities in 13%. Hema- turia was seen in 18% of recurrent abdominal pain group and in 5% of control group (P 0.08). Hypercalciuria was found in 13% of recurrent abdominal pain and 12% of control group (P 0.1). There was also no difference in urinary calcium-to-creatinine ratio and recurrent abdominal pain (0.11 ± 0.1 and 0.1 ± 0.08, respectively) (P 0.6).

The incidence of urolithiasis in this study (13%) is significantly higher than seen young population estimated is as much as 1%.[3]

In another study was performed on 124 chil- dren,[4] 42% of cases with recurrent abdominal pain had idiopathic hypercalciuria, whereas renal stones were seen in 11% which made to conclude that idiopathic hypercalciuria should be considered in the differential diagnosis of abdominal pain in children.[4]

In our study, idiopathic hypercalciuria was seen in only 12% and urolithiasis in 13% of the RAP cases. These differences among studies may be backed to different methods, sampling, geographical, and cultural selections.[2]

In conclusion, there are a few studies that evaluate the correlation between hypercal- ciuria, urolithiasis, and recurrent abdominal pain. It seems that RAP in children with hyper- calciuria is not more common significantly than children without hypercalciuria.


I dedicate this study to my leader Dr. Mohammad Mosadegh, God bless his soul.

Conflict of interest: None declared.


1Polito C, La Manna A, Signoriello G, Marte A. Recurrent abdominal pain in childhood urolithiasis. Pediatrics 2009;124:e1088-94.
2Vachvanichsanong P, Malagon M, Moore ES. Recurrent abdominal and flank pain in children with idiopathic hypercalciuria. Acta Paediatr 2001;90:643-8.
3Remzi D, Cakmak F, Erkan I. A study on the urolithiasis incidence in Turkish school-age children. J Urol 1980;123:608.
4Yousefi P, Cyrus A, Dorreh F, Gazerani N, Sedigh HR. Effect of hydrochlorothiazide on reducing recurrent abdominal pain in girls with idiopathic hypercalciuria. J Res Med Sci 2011; 16 Suppl 1:S433-6.