Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 29  |  Issue : 2  |  Page : 284--289

Association of brucellosis with renal tubular and glomerular damage in children in Turkey


Secil Conkar1, Muhammed Kosker2, Saliha Cevik3, Muzeyyen Ay3 
1 Department of Pediatric Nephrology, Ege University, İzmir, Turkey
2 Department of Pediatric Infectious Diseases, Children's Hospital, Diyarbakir, Turkey
3 Department of Infectious Diseases, Children's Hospital, Diyarbakir, Turkey

Correspondence Address:
Dr. Secil Conkar
Department of Pediatric Nephrology, Ege University, İzmir
Turkey

Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case–control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated. First-morning urine samples were collected from Group 1 and Group 2 at the same time. Urea, creatinine, potassium, sodium, and phosphorus were determined in serum and urine by an autoanalyzer. Tubular reabsorption and excretion of urine electrolytes were calculated using the related formulas. Patients with brucellosis had significantly lower levels of tubular reabsorption of phosphorus and serum phosphorus than those of the control group. Furthermore, urine sodium and serum potassium levels and fractionated sodium excretion of brucellosis patients were significantly higher than healthy control group. Estimated glomerular filtration rate was remarkably higher in the patient group (P < 0.001).We concluded that tubular and glomerular functional parameters demonstrate deterioration in patients with brucellosis compared to those in healthy participants.


How to cite this article:
Conkar S, Kosker M, Cevik S, Ay M. Association of brucellosis with renal tubular and glomerular damage in children in Turkey.Saudi J Kidney Dis Transpl 2018;29:284-289


How to cite this URL:
Conkar S, Kosker M, Cevik S, Ay M. Association of brucellosis with renal tubular and glomerular damage in children in Turkey. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2020 Jul 13 ];29:284-289
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=2;spage=284;epage=289;aulast=Conkar;type=0