Saudi Journal of Kidney Diseases and Transplantation

BRIEF COMMUNICATION
Year
: 2018  |  Volume : 29  |  Issue : 4  |  Page : 893--901

Study of glucocorticoid receptors in T lymphocytes (CD3/GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome


Ezzat Kamel Amin1, Mohamed A El-Gamasy2, Dina Mohammad Shokry1, Naglaa Ali Khalifa3 
1 Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Sharqia, Egypt
2 Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt
3 Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Sharqia, Egypt

Correspondence Address:
Mohamed A El-Gamasy
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Gharbia
Egypt

Little was known about the relationships between the T lymphocytes (CD3+), expression of glucocorticoid receptors (GCR) and the response to GC treatment in children with the idiopathic nephrotic syndrome (INS). Our objective was to determine the relation between steroid responsiveness and GCR expression in T lymphocytes. The present study was carried out on 80 children with new-onset INS admitted in Pediatric Nephrology Units of Zagazig and Tanta University Hospitals and on 40 healthy children of the same age and sex who served as control group. The Subjects were subdivided into three groups as follows: Group 1 with 40 healthy children of comparable age and sex served as control group; Group 2 consisted of 60 patients diagnosed with INS with early response to steroid therapy [early responder (ER)] and Group 3 with 20 patients diagnosed with INS with late response to steroid therapy [late responder (LR)]. They were subjected to history taking, focusing on the pattern of response to steroids (ERs), clinical examination, routine laboratory investigations and the GCR/CD3% relationship. 75% of newly diagnosed INS cases were ER whereas 25% were LR. GCR/CD3% was significantly lower in LR group in comparison with ER and control groups, with a significant negative correlation between time of steroid responsiveness and GCR/CD3%. LR group showed lower GCR expression in T lymphocytes before starting therapy which may mean that GCR expression could be part of a pathophysiological mechanism of steroid responsiveness in these children and can be used as a useful diagnostic marker to predict steroid responsiveness in patients with INS.


How to cite this article:
Amin EK, El-Gamasy MA, Shokry DM, Khalifa NA. Study of glucocorticoid receptors in T lymphocytes (CD3/GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome.Saudi J Kidney Dis Transpl 2018;29:893-901


How to cite this URL:
Amin EK, El-Gamasy MA, Shokry DM, Khalifa NA. Study of glucocorticoid receptors in T lymphocytes (CD3/GCR) as predictor of steroid responsiveness in Egyptian children with idiopathic nephrotic syndrome. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2020 Jul 15 ];29:893-901
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=4;spage=893;epage=901;aulast=Amin;type=0