Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2018  |  Volume : 29  |  Issue : 5  |  Page : 1232--1236

Hemosiderin tubulopathy-induced acute kidney injury - A rare initial manifestation of paroxysmal nocturnal hemoglobinuria


Srikanth Prasad Rao1, Sindhura Lakshmi Koulmane Laxminarayana2, Shankar Prasad Nagaraju1, Mahesha Vankalakunti3, Ravindra Prabhu Attur1, Chethan Manohar2 
1 Department of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India
2 Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India
3 Department of Pathology and Lab Medicine, Manipal Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Sindhura Lakshmi Koulmane Laxminarayana
Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal - 576 104, Udupi
India

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by episodes of intravascular hemolysis, infections, and thromboembolic complications. Renal abnormalities are rare which occur either due to hemolytic crisis or repeated thrombotic episodes involving small venules. Acute kidney injury (AKI) requiring hemodialysis due to toxic effects of hemoglobinuria, with a stable disease is exceptional. We describe a case of an elderly gentleman presenting with features of severe AKI requiring hemodialysis due to hemosiderin tubulotoxicity as the first manifestation of PNH. The diagnosis was challenging because of the rarity and unfamiliarity with this entity. The outcome was complete recovery of renal function with hemodialysis.


How to cite this article:
Rao SP, Laxminarayana SL, Nagaraju SP, Vankalakunti M, Attur RP, Manohar C. Hemosiderin tubulopathy-induced acute kidney injury - A rare initial manifestation of paroxysmal nocturnal hemoglobinuria.Saudi J Kidney Dis Transpl 2018;29:1232-1236


How to cite this URL:
Rao SP, Laxminarayana SL, Nagaraju SP, Vankalakunti M, Attur RP, Manohar C. Hemosiderin tubulopathy-induced acute kidney injury - A rare initial manifestation of paroxysmal nocturnal hemoglobinuria. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2019 Jun 20 ];29:1232-1236
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=5;spage=1232;epage=1236;aulast=Rao;type=0