Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 30  |  Issue : 4  |  Page : 769--774

High Serum Endothelin-1 Level is Associated with Poor Response to Steroid Therapy in Childhood-Onset Nephrotic Syndrome


Heba Mostafa Ahmed1, Dalia S Morgan1, Noha A Doudar2, Mariam S Naguib1 
1 Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt

Correspondence Address:
Heba Mostafa Ahmed
Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni Suef
Egypt

Nephrotic syndrome (NS) is one of the most common kidney diseases seen in children. It is a disorder characterized by severe proteinuria, hypoproteinemia, hyperlipidemia, and generalized edema resulting from alterations of permeability at the glomerular capillary wall. Endothelin-1 (ET1) has a central role in the pathogenesis of proteinuria and glomerulosclerosis and has a role in assessment of the clinical course of NS in children. This study aims to investigate the relationship between ET1 serum level and the response to steroid therapy in children with primary NS. Serum ET1 levels were evaluated in 55 children with NS. They were classified into two groups: 30 patients with steroid-sensitive NS (SSNS) and 25 patients with steroid-resistant NS (SRNS). The SSNS group was further divided into infrequent-relapsing NS (IFRNS) and steroid-dependent NS (SDNS), while the SRNS group was subdivided into two groups according to renal pathology. ET1 levels were significantly higher in the SRNS group (52.5 ± 45.8 pg/dL) compared to the SSNS group (18.3 ± 17 pg/dL) (P <0.001). Furthermore, ET1 levels were significantly higher in SDNS (54.3 ± 18.6) compared to IFRNS (11.9 ± 7.8, P = 0.001). There was no statistically significant difference in ET1 levels between minimal change disease group and focal segmental glomerulosclerosis group, (P = 0.28). Serum ET1 can be considered as a predictor for response to steroid therapy.


How to cite this article:
Ahmed HM, Morgan DS, Doudar NA, Naguib MS. High Serum Endothelin-1 Level is Associated with Poor Response to Steroid Therapy in Childhood-Onset Nephrotic Syndrome.Saudi J Kidney Dis Transpl 2019;30:769-774


How to cite this URL:
Ahmed HM, Morgan DS, Doudar NA, Naguib MS. High Serum Endothelin-1 Level is Associated with Poor Response to Steroid Therapy in Childhood-Onset Nephrotic Syndrome. Saudi J Kidney Dis Transpl [serial online] 2019 [cited 2019 Sep 21 ];30:769-774
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=4;spage=769;epage=774;aulast=Ahmed;type=0