Saudi Journal of Kidney Diseases and Transplantation

LETTER TO THE EDITOR
Year
: 2020  |  Volume : 31  |  Issue : 3  |  Page : 694--695

Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology


Won Sriwijitalai1, Viroj Wiwanitkit2,  
1 Private Academic Practice, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China

Correspondence Address:
Won Sriwijitalai
Private Academic Practice, Bangkok
Thailand




How to cite this article:
Sriwijitalai W, Wiwanitkit V. Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology.Saudi J Kidney Dis Transpl 2020;31:694-695


How to cite this URL:
Sriwijitalai W, Wiwanitkit V. Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2020 Sep 29 ];31:694-695
Available from: http://www.sjkdt.org/text.asp?2020/31/3/694/289457


Full Text



To the Editor,

Coronavirus infection becomes an important problem in public health. Within the past few years, many emerging coronavirus infections occur including to COVID-19.[1] The coronavirus-induced nephropathy is an interesting issue in clinical nephrology. The nephropathological finding is various.[2] In animal, the glomerulopathy by immune complex is an important clinical problem.[3] In fact, immune complex plays important role in many kinds of renal pathology and the underlying pathogenesis might be explained by nanostructure analysis.[4] Here, the authors focus interest on the coronavirus-antibody immune complex. The molecular nanostructure analysis by standard nanomedicine technique as used in the previous reported[5] was done. For prediction of the nanostructure of coronavirus-antibody immune complex, referencing sizes for coronavirus (120–160 nm),[1] immunoglobulin[6] and renal glomerulus (15–30 nm) diameters[5] are referred to. Based on nanostructure viewing of predicted immune complex, the size of coronavirus-antibody immune complex is 135–190 nm. This size is significant larger than glomerular pore size (4–4.5 nm)[4] but smaller than renal tubule (12–50 microns).[7] Therefore, there is a chance that the immune complex of coronavirus-antibody can cause glomerular pathology. This can also explain the observation of no virus in excreted urine during infection.[8]

Conflict of interest: None declared.

Dr. Won Sriwijitalai[1],

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