Close
 Indian J Med Microbiol  
 

Figure 2. Proposed model for protective mechanism of factor H and membrane co-factor protein (MCP) against complement activation (A,B) in their deficiency membrane bound C3b is not effectively inactive (iC3b), followed by formation of membrane attack complex C5b9, leading to expression of adhesive molecules (p-selection) that favors leukocyte attachment (C), endothelial damage and finally platelet (PLT) adhesion and aggregation (D).

Figure 2. Proposed model for protective mechanism of factor H and membrane co-factor protein (MCP)
against complement activation (A,B) in their deficiency membrane bound C3b is not effectively inactive
(iC3b), followed by formation of membrane attack complex C5b9, leading to expression of adhesive
molecules (p-selection) that favors leukocyte attachment (C), endothelial damage and finally platelet (PLT)
adhesion and aggregation (D).