Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 168 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

REVIEW ARTICLE Table of Contents   
Year : 1994  |  Volume : 5  |  Issue : 3  |  Page : 365-370
Etiopathogenesis of acute poststreptococcal glomerulonephritis

Department of Pediatrics, King Fahad National Guard Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Maha A Azzam
Department of Pediatrics, King Fahad National Guard Hospital, P.O. Box 22490, Riyadh 11426
Saudi Arabia
Login to access the Email id

PMID: 18583766

Rights and Permissions

The relationship between nephritogenic strains of group A beta-hemolytic streptococci (GABS) and acute poststreptococcal glomerulonephritis (APSGN) is well established. Recent studies have cast some doubts on the importance of the M-antigen which is widely used in classifying the nephritogenic strains of GABS. The renal injury occurs as a result of an immune-mediated process which involves the complement system. This leads to deposition of circulating immune complexes and/or their in-situ formation in the kidney resulting in renal damage. Newer antigenic fractions have been identified in GABS, which include; endostreptocin (ESS), nephritis strain associated protein (NSAP), and pre-absorbing antigen (Pa-Ag). These developments have allowed a better insight into the pathogenesis of APSGN.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded668    
    Comments [Add]    

Recommend this journal