|
|
| Year : 1999 | Volume
: 10
| Issue : 2 | Page : 187 |
|
| Immunoglobulin IgA Nephrology |
|
|
PT Subramanian
Consultant Nephrologist, Samatah General Hospital, Samatah, Gizan, Saudi Arabia
Click here for correspondence address and email
|
|
 |
|
How to cite this article:
Subramanian P T. Immunoglobulin IgA Nephrology. Saudi J Kidney Dis Transpl 1999;10:187 |
To the Editor:
I would like to thank E.N. Wardle [1] for providing enormous information on the molecular aspects of IgA nephropathy. I would like to get enlightened more on the following:
a) Protein Kinase C (PKC) is the key intermediary in the process by which transforming growth factor-beta TGF-Beta and angiotensin II promote mesangial cell matrix protein production. [2] However, this was not mentioned in Wardle's article. As Weiss and Al-Ramirez have shown the role of PKC inhibitor, will it be useful in arresting or postponing the progress if IgA nephropathy, which usually h an indolent course?
b) Chemoprophylaxis: is there a role of ACE inhibitors and/or anti-microbial prophylaxis in cases of synpharyngitis or syntonsillitis hematuria-proteinuria in order to arrest or postpone the progression of IgA nephropathy? If so, when and how long to prescribe?
 References | |  |
| 1. | Wardle En. Understanding immunoglobulin IgA nephropathy. Saudi J Kidney Dis Transplant 1998;9(4):444-50.  |
| 2. | Weiss RH. Al-Ramirez. TGF-Beta and angiotensin-II induced mesangial matrix protein secretion is mediated by protein Kinase C. Nephrol Dial Transplant 1998;13:2804-13. |
Correspondence Address:
P T Subramanian
Consultant Nephrologist, Samatah General Hospital, Samatah, Gizan
Saudi Arabia
  | Check |
PMID: 18212432 
|
|
|
|
|
|
|
|
|
|
