Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1332 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

ARTICLE Table of Contents   
Year : 2000  |  Volume : 11  |  Issue : 3  |  Page : 370-380
Lupus Nephritis among Arabs - Differences with other Races; Emphasis on Clinicopathological and Serological Perspectives


Department of Internal Medicine, Mafraq Hospital, Abu Dhabi, United Arab Emirates

Correspondence Address:
Haider M Al Attia
Department of Internal Medicine, Mafraq Hospital, P.O. Box 2951, Abu Dhabi
United Arab Emirates
Login to access the Email id


PMID: 18209329

Rights and Permissions

Data on ethnic differences of lupus nephritis (LN) are extremely scattered in the literature. Furthermore, most of the publications on LN in Arabs have in fact discussed the condition within the general frame of systemic lupus erythematosus (SLE) disease in mixed, but Arab-dominated groups of patients, and fewer, in exclusively Arab individuals. Lupus nephritis however, seems to be common, occurring in 37-69% of SLE patients in the Arab dominated groups and in 50% of the exclusively Arab group. In two out of three groups who reported their renal biopsy results, WHO class III was the most common histopathological type (36% and 54% respectively). Interestingly, the relatively high prevalence of nephropathy in the two groups was associated with a low prevalence of discoid lupus. Arabs with LN who have been studied for serological correlation, did not exhibit any specific or distinctive entity of autoantibody profile. Nonetheless, contradictory data have been noticed in relation to dsDNA antibodies, as they significantly correlated with LN in some of the Arab dominated groups, but not in the uniformly Arab group. Anti­RNP antibodies significantly correlated with non-nephritic SLE patients in the latter group, suggesting a possible protective role of these antibodies. The previously reported correlation between anti-Sm antibodies was not confirmed in the Arab groups. Like the other features of SLE, the differences related to LN in various populations are very likely to be multifactorial rather entirely being ethnical. Lupus nephritis in Arabs however, requires further demarcation by evaluating larger number of patients preferably through multicenter studies.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4203    
    Printed64    
    Emailed0    
    PDF Downloaded529    
    Comments [Add]    

Recommend this journal