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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2000  |  Volume : 11  |  Issue : 3  |  Page : 396-404
Immune Complex Glomerulonephritis in Patients with Hepatitis C

Department of Pathology, New York University, New York, NY 10016, USA

Correspondence Address:
Michael Barry Stokes
Department of Pathology, TH 480, New York University Medical Center, 560 First Avenue, New York, NY 10016
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PMID: 18209331

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Hepatitis C virus (HCV) may have a pathogenic role in several forms of immune complex glomerulonephritis (ICGN), including cryoglobulinemic membrano­proliferative glomerulonephritis (MPGN) and membranous nephropathy. HCV infection may also be related indirectly (e.g. secondary to HCV-related liver disease) or coincidentally to glomerulonephritis. These include cases of fibrillary/immunotactoid glomerulopathy, MPGN arising in allografts, allograft glomerulopathy, rapidly progressive glomerulo­nephritis, focal and segmental glomerulosclerosis, and ICGN arising in individuals co­infected with human immunodeficiency virus (HIV). This review summarizes the clinical and pathologic features of HCV-associated glomerular disease, particularly immune complex glomerulonephritis, and discusses possible pathogenic mechanisms.

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