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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2003  |  Volume : 14  |  Issue : 3  |  Page : 378-385
Familial Mediterranean fever and Renal Disease

University of Iowa Hospitals and Clinics, Department of Pediatrics, Division of Medical Genetics, USA

Correspondence Address:
Hatem I El-Shanti
University of Iowa Hospitals and Clinics, 2615 JCP, 200 Hawkins Drive, Iowa City, Iowa, 52242
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PMID: 17657110

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Familial Mediterranean Fever (FMF) is a genetic disorder frequently diagnosed among the Arabs. It is also prevalent among Jews, Armenians and Turks. The clinical picture consists of febrile and painful attacks such as joint or chest pain that differ in quality across patients and even within the same patient. The gene responsible for FMF, MEFV, has been cloned and mutations were identified within its coding sequence. It encodes a protein that is expected to be a down regulator of inflammation. The major renal involvement in FMF is the occurrence of amyloidosis that primarily affects the kidneys causing proteinuria and ending in death from renal failure. It can be treated by dialysis and renal transplantation, but can be prevented by a daily regimen of colchicine. Other renal manifestations of FMF are discussed.

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