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Saudi Journal of Kidney Diseases and Transplantation
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EDITORIAL Table of Contents   
Year : 2005  |  Volume : 16  |  Issue : 3  |  Page : 271-276
Pediatric Obstructive Uropathy: Clinical Trials

1 Professor of Pediatrics, University of Vermont and Director of Research, The Barbara Bush Childrenís Hospital, Maine Medical Center, Portland, Maine, USA
2 Division of Pediatric Nephrology, University of Kansas, Kansas City, KS, USA
3 Department of Pediatrics, Creighton University, Omaha, NE, USA

Correspondence Address:
James CM Chan
The Barbara Bush Childrenís Hospital, Maine Medical Center, 22 Bramhall Street, Portland, Maine 04102-3175
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PMID: 17642791

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As the powerful tools of molecular biology continue to delineate new concepts of pathogenesis of diseases, new molecular-level therapeutic modalities are certain to emerge. In order to design and execute clinical trials to evaluate outcomes of these new treatment modalities, we will soon need a new supply of investigators with training and experience in clinical research. The slowly-progressive nature of chronic pediatric kidney disease often results in diagnosis being made at a time remote from initial insult, and the inherently slow rate of progression makes changes difficult to measure. Thus, development of molecular markers for both diagnosis and rate of progression will be critical to studies of new therapeutic modalities. We will review general aspects of clinical trials and will use current and past studies as examples to illustrate specific points, especially as these apply to chronic kidney disease associated with obstructive uropathy in children.

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