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| ORIGINAL ARTICLE |
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| Year : 2005 |
Volume
: 16 | Issue : 3 | Page
: 288-292 |
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Correlation of Serum Parathormone with Hypertension in Chronic Renal Failure Patients Treated with Hemodialysis
Azar Baradaran1, Hamid Nasri2
1 Department of Biochemistry, The Center of Research and Reference Laboratory of Iran, Hospital Bu Ali, Damavand st.Tehran, Iran
2 Internist and Nephrologist, Shahrekord University of Medical sciences, Hajar Medical, Educational and Therapeutic Center, Section of Hemodialysis, Shahrekord, Iran
Correspondence Address:
Hamid Nasri
Shahrekord University of Medical sciences, Section of Hemodialysis, P.O. Box 88155-468, Shahrekord
Iran
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PMID: 17642794 
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To consider the correlation of serum parathormone on severity of hypertension in endstage renal disesase (ESRD) patients on hemodialysis (HD). A cross-sectional study was done on patients with ESRD on treatment with maintenance HD. Levels of serum calcium, phosphorus, alkaline phosphatase, albumin and intact parathormone (iPTH) were measured. Stratification of hypertensive patients was done from stages one to three. The total number of patients studied was 73 (Females=28, Males=45), consisting of 58 non-diabetic (F=22 M=36) and 15 diabetic patients (F=6 M=9). The mean age of the study patients was 46.5 ± 16 years.The mean duration on HD of the study patients was 21.5 ± 23.5 months. The mean serum PTH of the study patients was 309 ± 349 pg/ml and the mean serum alkaline phosphatase was 413 ± 348 IU/L. There was a significant positive correlation between the stage of hypertension and serum PTH levels (r =0.200 p=0.045). Also, there was a significant positive correlation between stage of hypertension and calcium-phosphorus product (r = 0. 231 p=0.027).There was no significant correlation between stage of hypertension and serum ALP (r =0.135 p=0.128). Relationship between serum PTH and severity of hypertension in patients on HD needs to be studied in more detail. Hypertention and secondary hyperparathyroidism interact in the process of accelerated atherosclerosis in HD patients thus warranting appropriate measures to control hyperparathyroidism vigorously. |
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