Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1380 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

ORIGINAL ARTICLE Table of Contents   
Year : 2006  |  Volume : 17  |  Issue : 4  |  Page : 497-502
Cyclosporine Utilization in Idiopathic Nephrotic Syndrome in Children


1 Pediatric nephrology department, Surgical Kidney Hospital, Ibn Alnafis Medical Complex, Syria
2 Nephrology unit, Al-Assad University Hospital, Damascus University, Damascus, Syria

Correspondence Address:
Bassam Saeed
Pediatric Nephrology Department Surgical Kidney Hospital, Ibn Alnafis Medical Complex, P.O. Box 8292, Damascus
Syria
Login to access the Email id


PMID: 17186683

Rights and Permissions

The treatment of steroid-resistant focal segmental glomerulosclerosis (FSGS) imposes one of the most perplexing and frustrating problems on nephrologists. Cyclosporine A (CsA) is widely considered as the treatment of choice for steroid-resistant or dependent nephrotic children. We reviewed the clinical outcome in children with idiopathic nephrotic syndrome (INS) under CsA treatment. A total of 22 children presented with either steroid­resistant nephrotic syndrome (SRNS) (14 children), or steroid-dependent nephrotic syndrome (SDNS) (8 children) during the period from August 2002 to February 2005; the mean age for both groups was 7.6 years (range: 23months -15 years). Renal histology showed FSGS in 14(63%) patients, minimal change disease (MCD) in 4(18%), diffuse mesangial glomerulonephritis (MesGN) in three (13.6%), and membranous glomerulonephritis (MGN) in two (6.8%). Treatment with CsA in combination with alternate-day prednisolone induced remission in 15(68%) patients; 9(60%) patients had complete remission and six (40%) had partial remission. Seven (50 %) patients in the SRNS group responded to CsA treatment; two (14.2%) patients had complete remission and 5 (35.7%) had partial remission. Seven (87.5%) children in the SDNS group had complete remission and one (13.5%) had partial remission. We conclude that this study demonstrates the efficacy of CsA in inducing remission in the steroid dependent is higher than in the steroid resistant nephrotic children We believe that CsA is probably a good alternative therapy in this population.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3660    
    Printed82    
    Emailed0    
    PDF Downloaded586    
    Comments [Add]    
    Cited by others 1    

Recommend this journal