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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2008  |  Volume : 19  |  Issue : 1  |  Page : 137-141
Amyloidosis and Vascular Thrombosis

Department of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Bappa Adamu
Nephrology Division, Department of Medicine, King Fahad Medical City, P.O. Box 59046, Riyadh 11525
Saudi Arabia
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PMID: 18087144

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Amyloidosis is a rare systemic disorder of protein metabolism with progressive extra­cellular deposition of insoluble fibrillary protein, disorganization of tissue architecture, and subsequent organ dysfunction. Primary amyloidosis is the most common form of this disorder, however, it can develop secondary to plasma cell dyscrasias such as multiple myeloma (MM); 10-15% of MM patients may develop amyloidosis of vital organs. Amyloidosis is usually associated with bleeding, but less commonly with thrombosis. We present a 52-year-old Saudi female with amyloidosis secondary to multiple myeloma. She presented with both venous and extensive arterial thrombosis. Although relatively rare, plasma cell dyscrasias such as amyloidosis and multiple myeloma could present with thrombotic rather than hemorrhagic complications.

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