Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 2011 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 

ORIGINAL ARTICLE Table of Contents   
Year : 2008  |  Volume : 19  |  Issue : 2  |  Page : 222-226
Comparison of Right and Left Grafts in Renal Transplantation


Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Iran

Click here for correspondence address and email
 

   Abstract 

This study compares outcomes and graft function of right and left grafts of deceased donor. We studied 120 kidney recipients from 60 deceased donors in Shiraz organ transplantation center from 1988 to 2004. We analyzed data regarding age, gender, side of grafts, duration of pre-transplant dialysis, hospital stay, serial creatinine levels, cold ischemic time, complications, graft function, patient survival rates, and post-operative complications. Recipients were divided into two groups: group 1 consisted of 60 recipients who received right renal graft (43 males, 17 females; mean age: 33.6 ± 7.3 years), and group 2 consisted of 60 recipients who received left renal graft (45 males, 15 females; mean age: 29.2 ± 6.4 years). No statistically significant differences were found in duration of pre-transplant dialysis, cold ischemic time, acute rejection rates, post-operative surgical and vascular complications' rates, hospital stay, renal function, and one year graft survival rates. We conclude that although it is advised to use left kidney from live donors because of longer vessel length, easier surgical technique and organ handling, and shorter ischemic time, we got the same outcome in left and right deceased renal grafts.

Keywords: Graft survival, kidney transplantation, left kidney, post-operative complications, right kidney

How to cite this article:
Salehipour M, Bahador A, Jalaeian H, Salahi H, Nikeghbalian S, Khajehee F, Malek-Hosseini SA. Comparison of Right and Left Grafts in Renal Transplantation. Saudi J Kidney Dis Transpl 2008;19:222-6

How to cite this URL:
Salehipour M, Bahador A, Jalaeian H, Salahi H, Nikeghbalian S, Khajehee F, Malek-Hosseini SA. Comparison of Right and Left Grafts in Renal Transplantation. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2020 Oct 23];19:222-6. Available from: https://www.sjkdt.org/text.asp?2008/19/2/222/39034

   Introduction Top


Renal transplantation is the method of choice for treatment of patients with end-stage renal failure. Although the number of live-donor renal transplants has increased steadily over the past decade, deceased transplants continue to outnumber live-donor transplants by three to one, worldwide. [1] The results of deceased renal transplantation are dependent on many variables of the donors including age, gender, race, body size, cause of death, terminal renal function, comorbidities, and beating vs. non­ beating heart. [2],[3]

There is limited evidence suggesting that due to technical complications stemming from the disparity in the lengths of the left and right renal veins, [4],[5] the renal left or right grafts may impact significantly the outcome. [6],[7]

However, in light of the substantial improve­ments in renal transplant outcomes achieved over the last decade, some studies have ques­tioned whether left kidney transplantation continues to be a contemporary, independent predictor of early post-transplant graft survival. [3]

We aim in this the present study to compare the outcomes and graft function of right and left deceased renal grafts.


   Material and Methods Top


We retrospectively analyzed the outcomes of 60 left-right pairs of deceased renal grafts transplanted into 120 recipients with end-stage renal failure in Shiraz organ trans­plantation center from 1988 to 2004. In order to ensure that all other donor factors were equally represented in the study groups, reci­pients were not included if one or both renal allografts were shipped to another center for kidney transplantation. The preservation fluid was the University of Wisconsin solution. The recipients immunosuppressive therapy included a calcineurin inhibitor (cyclosporine or tacro­limus), prednisolone, and either azathioprine or mycophenolate mofetil (MMF).

We studied the patients' demographic data, operative data, post-operative complications, medical complications, and renal allograft function prospectively recorded on a compu­terized integrated renal database. Duration of pre-transplant dialysis, length of hospital­lization, cold ischemia times, serial serum creatinine levels, post operative complications, graft function, and survival rates were com­pared between the two groups. All transplant recipients were followed up until death or to the end of the study.

The transplant procedures were performed by 6 experienced transplant surgeons over the study period. The transplants were allocated evenly, and a standard operative procedure was employed by all the surgeons. In the absence of other factors (e.g. previous transplants, abdominal scarring, ipsilateral peritoneal dia­lysis catheters), the renal grafts were implanted on the contralateral side, i.e. right kidneys to the left and left kidneys to the right to allow medial positioning of the collecting system. Left kidneys were used where possible for the recipient who was judged to be more techni­cally challenging (e.g. obese or previous pelvic surgery) because of the greater flexibility afforded by the longer vein.


   Statistical analysis Top


Data were analyzed using the software package, SPSS for Windows release 13.0 (SPSS Inc., Chicago, Ill). Comparisons between the recipients of left and right donor kidneys were performed using Student's "t" test. Diffe­rences in proportions were evaluated by the chi-square test or Fisher's exact test, as appro­priate. Death-censored graft survival curves, survival probabilities and estimated mean survival times were generated according to the Kaplan-Meier method. Differences in the sur­vival curves between the two groups were evaluated using the log rank test. P values of 5% or less was considered statistically significant.


   Results Top


Recipients were divided into two groups: group 1 consisted of 60 recipients (43 males, 17 females) who received right renal graft while group 2 recipients (45 males, 15 females) re­ceived left kidney. Donor characteristics were identical in both groups due to the inclusion only of kidney transplant recipient pairs in our study.

[Table - 1] shows the baseline characteristics of the recipients in both groups. There was no statistically significant difference in the mean age, sex ratio, preoperative creatinine, and duration of pre-transplant dialysis between the study groups. Furthermore, no statistical diffe­rences were observed with respect to hospi­talization duration (22.7 ± 3.5 vs. 21.3 ± 2.9 days) and cold ischemic time (3.4 ± 1.2 vs. 3.6 ± 1.0 hours).

The complications observed within the first year of renal transplantation are also presented in [Table - 1]. No significant differences were observed between recipients of left and right kidneys, even when a composite of vascular, hemorrhagic, infective and ureteric compli­cations was analyzed.

During the period of the study, 22 patients in the left kidney group developed acute graft rejection compared with 26 patients in the right kidney group (p = 0.4). Actuarial graft survival was comparable between the two groups (p = 0.5); respective death-censored graft survivals for right and left kidney recipients were 94 and 98% at 1 month, 88 and 96% at 3 months, and 80 and 84% at 12 months, respectively.

Postoperative recipient graft function as assessed by serial creatinine levels at 1, 3, and 12 months postoperatively revealed no significant difference; mean serum creatinine concentrations were similar in the right and left kidney recipient groups at 1 month (0.8 vs. 1.0 mg/dL, respectively, p = 0.9), 3 months (0.9 vs. 0.7 mg/dL, p = 0.8), and 1 year (0.8 vs. 1 mmol/L, p = 0.9). Finally, there were no statistically significant differences in patient survivals for right and left kidney recipients at 1, 3 and 12 months were n (p = 0.5).


   Discussion Top


Previously, most surgeons preferred to do most nephrectomy procedures on the left side owing to technical difficulties and renal vessel length. It has been suggested that the shorter length of the right renal vein may make it more difficult to perform the venous anastomosis in right kidney deceased donor transplantation, especially in obese subjects in whom the iliac vessels are deep, thereby leading to an increased risk of surgical complications. [4]

The present study demonstrated that the deceased renal graft side did not appreciably impact on early post-operative outcomes. Moreover, recipients of right donor kidneys exhibited comparable renal allograft function and death-censored graft survival rates to those patients transplanted with left donor kidneys.

Our findings are supported by those of Roodnat et al [2] and Johnson et al [3] who simi­larly did not observe any difference in graft outcomes between left and right kidney reci­pients at their centers. Similar findings have also been reported for laparoscopic live donor renal transplant operations. [8],[9] Shokeir et al suggested that the kidney with less function be chosen for donor nephrectomy regardless of anatomical considerations. [10]

However, these results contrast with those of the two previous UNOS Registry studies in the late 1980s/early 1990s, which demons­trated a graft survival benefit associated with transplanting left kidneys. [6],[7] It is probable that recent improvements in transplant outcomes may have abrogated any benefit associated with donor kidney side.

Also, the technical challenges presented by the relatively short length of the right renal vein may be at least partially counter­balanced by difficulties presented by the more frequent anatomical variations in the left renal vein, particularly the greater fre­quency of additional renal veins and circum­aortic left renal veins. [11]

In addition, previously Roodnat et al found that the one and most important avoidable risk factor for graft failure censored for death appears to be an increased cold ischemia time. [2] As we transplant right and left kidneys on two recipients by two transplantation teams, in two operating theaters simul­taneously, the cold ischemic times were comparable in our patients for left and right kidney transplantation.

In conclusion, although left and right de­ceased donor renal grafts present different operative challenges, the present results suggest that the probability of early post-operative complications, delayed graft function, impaired early and medium-term renal allograft function, and graft and patient survival is comparable between left and right renal graft recipients.

 
   References Top

1.El-Diasty TA, El-Ghar ME, Shokeir AA, et al. Magnetic resonance imaging as a sole method for the morphological and functional evaluation of live kidney donors. Br J Urol Int 2005;96(1):111-6.  Back to cited text no. 1    
2.Roodnat JI, Mulder PG, Van Riemsdijk IC, Jzermans JN, van Gelder T, Weimar W. Ischemia times and donor serum creatinine in relation to renal graft failure. Transplantation 2003;75(6):799-804.  Back to cited text no. 2    
3.Johnson DW, Mudge DW, Kaisar MO, et al. Deceased donor renal transplantation-does side matter? Nephrol Dial Transplant 2006; 21(9):2583-8.  Back to cited text no. 3    
4.Janschek EC, Rothe AU, Holzenbein TJ, et al. Anatomic basis of right renal vein extension for deceased kidney transplantation. Urology 2004;63(4):660-4.  Back to cited text no. 4    
5.Satyapal KS, Kalideen JM, Singh B, Haffejee AA, Robbs JV. Why we use the donor left kidney in live related transplantation. S Afr J Surg 2003;41(1):24-6.  Back to cited text no. 5    
6.Gjertson DW. Multifactorial analysis of renal transplants reported to the United Network for Organ Sharing Registry. Clin Transpl 1992;:299-317.  Back to cited text no. 6  [PUBMED]  
7.Feduska NJ Jr, Cecka JM. Donor factors. Clin Transpl 1994;:381-94.  Back to cited text no. 7  [PUBMED]  
8.Swartz DE, Cho E, Flowers JL, et al. Laparoscopic right donor nephrectomy: Technique and comparison with left nephrec­tomy. Surg Endosc 2001;15(2):1390-4.  Back to cited text no. 8    
9.Liu KL, Chiang YJ, Wu CT, Lai WJ, Wang HH, Chu SH. Why we consistently use the left donor kidney in living related transplantation: Initial experience of right laparoscopic donor nephrectomy and comparison with left nephrectomy. Transplant Proc 2006;38 (7):1977-9.  Back to cited text no. 9    
10.Shokeir AA, Gad HM, el-Diasty T. Role of radioisotope renal scans in the choice of nephrectomy side in live kidney donors. J Urol 2003;170(2.1):373-6.  Back to cited text no. 10    
11.Satyapal KS, Kalideen JM, Haffejee AA, Singh B, Robbs JV. Left renal vein variations. Surg Radiol Anat 1999;21(1):77-81  Back to cited text no. 11    

Top
Correspondence Address:
Mehdi Salehipour
Assistant Professor of Urology, Fellowship of Renal Transplantation, Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz
Iran
Login to access the Email id


PMID: 18310871

Rights and Permissions



 
 
    Tables

  [Table - 1]

This article has been cited by
1 Inferior early posttransplant outcomes for recipients of right versus left deceased donor kidneys: An ANZDATA registry analysis
Vacher-Coponat, H. and McDonald, S. and Clayton, P. and Loundou, A. and Allen, R.D.M. and Chadban, S.J.
American Journal of Transplantation. 2013; 13(2): 399-405
[Pubmed]
2 Graft survival rate in pediatric renal transplantation: A single center experience
Almasi-Hashiani, A. and Rajaeefard, A. and Hassanzade, J. and Salahi, H. and Mehrabani, D. and Khedmati, E.
Pakistan Journal of Medical Sciences. 2012; 28(5): 9
[Pubmed]



 

Top
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    Abstract
    Introduction
    Material and Methods
    Statistical analysis
    Results
    Discussion
    References
    Article Tables
 

 Article Access Statistics
    Viewed4369    
    Printed62    
    Emailed0    
    PDF Downloaded1243    
    Comments [Add]    
    Cited by others 2    

Recommend this journal