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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO THE EDITOR Table of Contents   
Year : 2008  |  Volume : 19  |  Issue : 2  |  Page : 254-255
Controversial role of Omega-3 fatty acids in Dyslipidemia


1 Department of Endocrinology, Medwin Hospitals, Chirag Ali Lane, Nampally, Hyderabad-500 001, India
2 Department of Nephrology, Medwin Hospitals, Chirag Ali Lane, Nampally, Hyderabad-500 001, India

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How to cite this article:
Hari Kumar K, Verma A, Shekhar, Modi K D. Controversial role of Omega-3 fatty acids in Dyslipidemia. Saudi J Kidney Dis Transpl 2008;19:254-5

How to cite this URL:
Hari Kumar K, Verma A, Shekhar, Modi K D. Controversial role of Omega-3 fatty acids in Dyslipidemia. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2020 Dec 5];19:254-5. Available from: https://www.sjkdt.org/text.asp?2008/19/2/254/39041
To the Editor:

We have read the article "The effect of Low Dose Omega-3 on Plasma Lipids in Hemodialysis Patients" by Taziki O et al [1] and we have few queries for which clari­fication is required from the authors:

  1. The context and design of the study appears inappropriate because chronic kidney disease (CKD) patients have high risk of cardiovascular mortality. As per KDOQI guidelines the primary target should be LDL lowering to less than 100 mg/dl. [2] All the participants in the study have LDL > 100 mg/dl and the authors have not addressed this in their study exposing the patients to higher risk of cardiovascular events.
  2. Omega -3 fatty acids alone have debatable efficacy in lowering triglyceride levels and a recent meta analysis did not show a signi­ficant reduction in cardiovascular events or mortality with the use of dietary or pharma­cologic fatty acid supplementation. [3],[4]
  3. The baseline triglyceride level in the drug group was significantly higher than in the control group (321 ± 29 vs 268 ± 22). Both groups should have matching data when an intervention is being studied. Could this be the cause of the apparent benefit with fatty acid supplementation? The data regarding baseline triglycerides of the control group in the two tables is different (Table 1 - - 268 ± 22, Table 2 - - 268 ± 32).
  4. The fasting serum total cholesterol should be more than 220 mg/dl as per the inclusion criteria. However, in Table 2 the baseline levels provided for both groups (102 ± 32, 229 ± 31) were not in keeping with the inclusion criteria.
  5. The authors mentioned that in their study, regular fish intake or pharma­cological treatment with N-3 PUFA has favorable effect on serum lipids in patients on HD. However, no data regarding the fish intake is provided in the article.


We would like to thank the authors for an interesting paper highlighting the importance of managing dyslipidemia in CKD patients.

 
   References Top

1.Taziki O, Lessan-Pezeshki M, Akha O, Vasheghani F. The effect of Low Dose Omega-3 on Plasma Lipids in Hemodialysis Patients. Saudi J Kidney Dis Transpl 2007; 18(4):571-6.  Back to cited text no. 1    
2.National Kidney Foundation: K/DOQI Clinical Practise Guidelines for Treating Dyslipidemias in Chronic Kidney Disease. Am J Kidney Dis 2003;41(4):S39-58.  Back to cited text no. 2    
3.Brunzell JD. Hypertriglyceridemia: Clinical practice. N Engl J Med 2007;357:1009-17.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease and cancer: Systematic review. BMJ 2006;332:752-60.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]

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Correspondence Address:
KVS Hari Kumar
Department of Endocrinology, Medwin Hospitals, Chirag Ali Lane, Nampally, Hyderabad-500 001
India
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PMID: 18310879

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