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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2008  |  Volume : 19  |  Issue : 3  |  Page : 401-403
Predictors of Hyperparathyroidism in Renal Transplant Recipients


Service de Nephrologie, Dialyse, Transplantation, CHU Ibn Sina, Rabat, Maroc, Morocco

Correspondence Address:
Tarik Sqalli Houssaini
Service de Nephrologie, Dialyse, Transplantation, CHU Ibn Sina, Rabat, Maroc
Morocco
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PMID: 18445900

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The changes in parathyroid hormone secretion after successful renal transplantation remain to be clearly elucidated. Our study was aimed at identifying the predictors of hyperpara­thyroidism in renal transplant recipients. A retrospective single center study involving 37 renal transplant recipients, with a follow-up of at least one year, was performed. All transplants were performed using kidneys from living related donors. The average age of the study patients was 30 ± 10 years, with a male-female ratio of 1.31. The mean duration on hemodialysis (HD) prior to transplantation was 25 ± 18 months. All the grafts but one, were functional after a mean follow-up of 41 ± 21 months. We noted a rapid reduction of the mean parathyroid hormone (iPTH) level from 383 ± 265 pg/ml before transplantation to 125 ± 67 pg/ml at one year and 108 ± 66 pg/ml at two years after transplantation (p = 0.01). Bivariate analysis revealed that the level of iPTH obtained during follow-up correlated with the duration on HD (p = 0.03), the serum creatinine at 24-months (p = 0.013), and to the level of iPTH in the first year post­transplantation (p = <0.001). Other clinical or laboratory parameters were not predictive of hyperpara­thyroidism after kidney transplantation. Linear regression showed that only the serum creatinine at 24­months independently correlated with the level of iPTH at last follow-up (p = 0.02). Our study suggests that short duration on HD and a functional graft are the main predictors of correction of hyperparathyroidism after renal transplantation.


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