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| REVIEW ARTICLE |
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| Year : 2009 |
Volume
: 20 | Issue : 5 | Page
: 741-752 |
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The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review
Ahmed Ragheb1, Ahmed Attia1, Walid Shehab Eldin1, Fawzy Elbarbry2, Sana Gazarin3, Ahmed Shoker1
1 Department of Medicine, Division of Nephrology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
2 School of Pharmacy, Pacific University, Hillsboro, OR, USA
3 Department of General Medicine, College of Medicine, Menofyia University, Menofyia, Egypt
Correspondence Address:
Ahmed Shoker
Department of Medicine Division of Nephrology University of Saskatchewan 103 Hospital Drive, Saskatoon SK S7N 0W8
Canada
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PMID: 19736468 
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Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including antioxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans. |
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