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Saudi Journal of Kidney Diseases and Transplantation
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REVIEW ARTICLE Table of Contents   
Year : 2009  |  Volume : 20  |  Issue : 5  |  Page : 741-752
The protective effect of thymoquinone, an anti-oxidant and anti­-inflammatory agent, against renal injury: A review

1 Department of Medicine, Division of Nephrology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
2 School of Pharmacy, Pacific University, Hillsboro, OR, USA
3 Department of General Medicine, College of Medicine, Menofyia University, Menofyia, Egypt

Correspondence Address:
Ahmed Shoker
Department of Medicine Division of Nephrology University of Saskatchewan 103 Hospital Drive, Saskatoon SK S7N 0W8
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Source of Support: None, Conflict of Interest: None

PMID: 19736468

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Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti­oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulo­nephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demons­trated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.

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