Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1416 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

CASE REPORT Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 1  |  Page : 109-112
Response to rituximab in a refractory case of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus

Department of Medicine, Division of Nephrology and Division of Hematology/Oncology, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Faraz Azim Niaz
Department of Medicine, College of Medicine and King Khalid University Hospital,P.O. Box 7805, Riyadh 11472
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 20061703

Rights and PermissionsRights and Permissions

Thrombotic thrombocytopenic purpura (TTP) is a serious disorder with a significant morbidity and mortality. Majority of cases of TTP are idiopathic, but some cases may be secon­dary to connective tissue diseases. TTP has been rarely associated with systemic lupus erythe­matosus (SLE) and may be refractory to treatment with plasma exchange, requiring immuno­suppressive therapy. We describe a patient with TTP and SLE who was refractory to plasma exchange and corticosteroids but responded to anti-CD20 antibody rituximab with continued re­mission after eight months of follow-up. Rituximab appears to be an effective treatment in re­fractory cases of TTP associated with SLE.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1284    
    Comments [Add]    
    Cited by others 4    

Recommend this journal