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| ORIGINAL ARTICLE |
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| Year : 2010 |
Volume
: 21 | Issue : 1 | Page
: 69-74 |
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Prognostic value of insulin- like growth factor-I receptor expression in renal cell carcinoma
Mehrdad Mohammadi Sichani1, Fateme Sarreshtedar Yazdi2, Noushin Afshar Moghaddam2, Ali Chehrei2, Mahmud Kabiri1, Amin Naeimi3, Diana Taheri2
1 Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of English, School of Humanities, Yazd University, Yazd, Iran
Correspondence Address:
Diana Taheri
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
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PMID: 20061696 
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The Insulin-Like growth factor-I receptor (IGF-IR), a tyrosine-kinas receptor over expressed in many tumor cell lines and in some human tumors, plays a critical role in transformation, tumorigenicity and metastasis. The aim of the present study is to investigate the role of IGF-IR expression as a prognostic factor in RCC. This study was conducted in a historical cohort of 82 patients who had RCC treated with radical nephrectomy from 1994 to 2005. Specimens were reevaluated with regard to histological subtype, nuclear grade, stage and IGF-IR expression. The IGF-IR stain was semi- quantitatively evaluated using the Allred score system. Kaplan-Meier analysis demonstrated a significant positive correlation between Fuhrman nuclear grade and IGFIR Allred score (P< 0.0001). Survival in patients with score IGF-I ≤ 4 was 90.21 month and in patients with score IGF-1R> 4 was 33.39 month (P Value < 0.0001). Cox regression analysis indicated that expression of IGF-IR is a prognostic factor in patients with RCC (P Value < 0.0001, odds Ratio = 2.38). In conclusion, a statistically significant correlation was demonstrated between IGF-IR expression and Fuhrman nuclear grading and survival in patients with RCC. In stage-bystage and grade-by-grade analysis; however, it seems that we cannot consider IGF-IR as an independent prognostic factor. |
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