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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 1  |  Page : 87-92
The long-term results of pediatric patients with primary focal and segmental glomerulosclerosis

1 Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
2 Department of Pathology, Faculty of Medicine, Ege University, Izmir, Turkey

Correspondence Address:
Betul Sozeri
Department of Pediatrics, Faculty of Medicine, Ege University, Izmir
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Source of Support: None, Conflict of Interest: None

PMID: 20061699

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Focal and segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid­resistant nephrotic syndrome (SRNS) and end-stage renal disease (ESRD). In this retrospective study, we report on 34 pediatric patients with FSGS who were diagnosed and treated from 1992 to 2006. The mean age at onset was 6.3 ± 4.3 years. All patients had nephrotic-range proteinuria. Micros­copic hematuria was seen in three patients and hypertension was seen in 15 patients at presentation. All patients were treated with steroids (oral and/or methylprednisolone), while 23 patients received cytotoxic therapy in addition. The mean follow-up period was 8.6 ± 3.3 years at the end of which, 59% of patients achieved complete or partial remission, 20.5% continued to have active renal di­sease while 20.5% of the patients developed CKD. Our study suggests that most of the patients with FSGS progress to renal insufficiency. Steroid therapy increases the chances of remission and pre­serves renal function in patients with sporadic primary FSGS.

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