Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1217 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 

ORIGINAL ARTICLE Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 2  |  Page : 251-257
Surgical complications in pediatric and adolescent renal transplantation


1 Department of Urology, Charles Nicolle Hospital, Tunis, Tunisia
2 Department of Pediatric, Charles Nicolle Hospital, Tunis, Tunisia

Click here for correspondence address and email

Date of Web Publication9-Mar-2010
 

   Abstract 

To report the surgical complications among our pediatric and adolescent renal transplants and to compare these results with other reported series in the literature. A total of 50 pediatric and adolescent renal transplants were included in this study. There were 30 boys and 20 girls with a mean age of 13 years (range 6 - 18 years). 70% of patients received their kidneys from living donors. Two patients underwent renal re-transplantation. Among the 52 transplantations, 17 surgical complications were encountered in 15(30%) patients. The incidence of urological and vascular complications was respectively 13.2% and 18.9%. These complications included vesico­ureteral reflux (9.4%), urinary leakage (3.8%), lymphocele (5.8%), peri-renal hematoma (1.9%), renal artery stenosis (3.7%), and thrombosis of the allograft (7.5%). The patients with vesico­ureteral reflux were treated by antibiotic prophylaxis. In four recipients, thrombosis of the allo­graft with subsequent graft loss occurred. The graft survival rate was 90% in 1 year, 77% in 5 years and 40% in 10 years follow-up. The patient survival rate was 94.4% in 1 year and 84% after 8 years follow-up. We conclude that surgical complications can be minimized if basic principles of careful transplant techniques are used. Prompt identification and treatment of any complication are critical for graft and patient survival.

How to cite this article:
El Atat R, Derouiche A, Guellouz S, Gargah T, Lakhoua R, Chebil M. Surgical complications in pediatric and adolescent renal transplantation. Saudi J Kidney Dis Transpl 2010;21:251-7

How to cite this URL:
El Atat R, Derouiche A, Guellouz S, Gargah T, Lakhoua R, Chebil M. Surgical complications in pediatric and adolescent renal transplantation. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2020 Oct 21];21:251-7. Available from: https://www.sjkdt.org/text.asp?2010/21/2/251/60062

   Introduction Top


Renal transplantation is the therapy of choice in end-stage renal failure in children. Although rejection is the main cause of graft failure, sur­gical complications can also play a role in graft loss and even patient mortality.

The incidence of surgical complications after kidney transplantation has been reported to range from 1 to 33%, [1],[2],[3],[4] data are not really com­parable because some author include only ma­jor surgical complications, whereas others even include urinary tract infections.

We performed a retrospective study of surgi­cal complications in our pediatric transplant patients and compared these results with other reported series.


   Subjects and Methods Top


From June 1986 to December 2007, 409 kidney transplantations were performed in our insti­tution, including 50 children and adolescents who comprised the study group. There were 30 boys and 20 girls with a mean age of 13 years (range 6 - 18 years). Their weights ranged from 15 to 59 Kg (mean of 32 kg). Thirty-five (70%) patients received their kidneys from living do­nors, and 2 patients underwent re-transplanta­tion. All patients were treated with dialysis prior to transplantation.

We used the standard open surgical technique with a right pararectal incision with an extra­peritoneal approach. We used the common iliac for arterial anastomosis in 50 cases, and the hypogastric artery in 2 cases. The venous anas­tomosis was performed with the external iliac vein in all the cases. There were no cases of bladder enlargement previous to transplanta­tion. The uretero-vesical re-implant in all the cases was extra-vesical through the Lich­Gregoir technique associated with ureteral stent.


   Results Top


Among the 52 transplantations, 17 surgical complications occurred in 15 patients. The o­verall rate of surgical complication was 32%. These complications included are shown in the [Table 1]. The incidence of urological complica­tions and vascular complications were respec­tively 13.2% and 18.9%.

Urinary leakage was observed in 2 patients, ureteral in one case and calyceal in the other case; the interval to diagnosis was 2 weeks, and symptoms included sudden oliguria and an increasing serum creatinine level. The leakage was treated by antegrade fixation of a ureteric stent.

The calyceal fistula was secondary to an ac­cidental ligation of polar vessels; the upper pole of the graft was infracted. Upper polar partial nephrectomy was performed and the repair was reinforced by an omental patch.

The characteristics and the management of the patient with vesico-ureteral reflux are shown in the [Table 2].

Asymptomatic lymphocele was diagnosed in 3 patients. The diagnosis was made with ultra­sonography and confirmed by needle aspira­tion of the lymphocele content and estimation of the creatinine concentration. The treatment was conservative in the 3 cases due to the small volume of the collections.

Renal artery stenosis was reported in 2 of our patients. Both patients presented with hyper­tension had a normal serum creatinine level and were successfully treated with antihyper­tensive medications.

In 4 recipients, thrombosis of the allograft with subsequent graft loss occurred. One pa­tient had a significant peri-renal hematoma, which presented in the immediate postoperative period with a decreasing hematocrit and hypo­tension requiring blood transfusion.

During the follow-up period, 10 grafts were lost due to chronic rejection and 4 patients died. There were 4 losses of grafts due to surgical complications. The patient survival rate [Figure 1] was 94.4% in 1 year, and 84% after 8 years follow-up. The graft survival rate [Figure 2] was 90% in 1 year, 77% in 5 years and 40% in 10 years follow-up.


   Discussion Top


Surgical complications represent the most co­mmon complication after pediatric renal trans­plantation and may be associated with signifi­cant morbidity.

A summary of urological complications in pediatric patients reported in the literature and our own series is given in [Table 3].

Urological complications can be a real threat to the graft and even patient survival. In the literature especially urinary leakage and obs­truction have a considerable mortality rate. In our study, no patient died because of urologi­cal complications.

Ureteric obstruction may occur in either the early or the late postoperative period, while ure­teral fistula is generally evident early after transplantation. Technical problems can induce ureteric vascular insufficiency, such as tran­sient hypotension with vascular declamping compromising the already marginal ureteral blood supply and failure to preserve ureteral blood supply during procurement by not adhe­ring to principles of proper dissection.

The use of graft percutaneous nephrostomy in the initial management of ureteral complica­tions significantly improved graft survival and function and reduced the incidence of post­treatment complications. [15] Patients initially trea­ted by graft percutaneous nephrostomy, endo­urologic procedures (ureteral stent, antegrade balloon dilatation) provided definitive manage­ment in 40% of case with small ureteral fistula and in 28% of cases with ureteral obstruction. Surgery is required for the leaks associated with ureteral necrosis and for the late and severe cases of ureteral obstruction.

Calyceal fistula is serious sequelae of renal transplantation occurring in approximately 3% of allografts. The urinary leak is usually secon­dary to infarction due to ligation of polar ve­ssels or damage during retrieval or bench sur­gery. Early intervention is mandatory to avoid wound infection and systemic infection which could be fatal. [17]

In a series of 543 renal transplants, 6 patients suffered a post transplant renal segmental in­farct and developed calyceal fistulas between 9 and 17 days. [18] They were treated by partial (25 to 40%) transplant nephrectomy, followed by closure and tissue coverage.

The frequency of post-transplant vesico-ure­teral reflux (VUR) in children and the factors that favor the development of VUR are poorly known, and studies published to date have yiel­ded contradictory findings. The higher occur­rence of post-transplant VUR (34 - 36%) in children has been reported in some studies, [19],[20],[21],[22] while the occurrence of surgery for post-trans­plant VUR in pediatric patients is 5.5%. In our study, we did not screen systematically for post-transplant VUR. The appearance of VUR may depend on the time elapsed between transplantation and diagnostic studies to detect this complication, and the type of uretero-ve­sical anastomosis used. [23],[24] In an earlier pros­pective, randomized trial, [25] VUR was less fre­quent when the Leadbetter-Politano technique was used. However, like most transplant teams, we used an extra-vesical approach because it is associated with lower rates of post-surgical complications, and requires shorter segments of ureters and less operating time to perform. A number of authors [26],[27],[28],[29],[30],[31],[32],[33] have noted that the presence of VUR is not associated with an in­crease in the frequency of post-transplant uri­nary tract infection. According to French and Fontana et al, [34],[35] VUR did not affect graft func­tion in the short and long-term. The surgical treatment was performed only when UTI ap­peared despite antibiotic prophylaxis, or after antibiotics were withdrawn 6 months after trans­plantation. In some patients, a less invasive en­doscopic technique may be useful. Cloix et al [36] and Mallet et al, [37] reported success rates of 30% and 53%, respectively.

Lymphocele represents an extraperitoneal co­llection of lymph created by division of lym­phatic vessels, and it is best prevented by meti­culous sequential lymphatic ligation during re­cipient vessel exposure, and by limiting the extent of dissection to that needed for safe pro­ximal and distal vascular control. [3] Shokeir [15] treated his patients with symptomatic lympho­cele successfully with percutaneous catheter drainage and sclerotherapy with an overall success rate of 50%. Should catheter drainage fail, laparoscopic marsupialization is usually effective .[38]

Renal artery stenosis was reported in only two of our patients. Both patients presented with hypertension and were successfully trea­ted with antihypertensive medications. Zaontz et al [6] summarized the etiological factors of re­nal artery stenosis as faulty surgical technique, trauma to the donor kidney from the perfusion canula or intimal tears from overstretching the artery, or artery angulation secondary to excessive length from end-to-end anastomosis with the hypogastric artery. [6] Surgical correction of renal artery stenosis may be indicated in pa­tients with either intractable hypertension and/ or deteriorating renal function. Radiographic angioplasty to relieve renal artery/segmental stenosis is especially difficult in children. [6]

Renovascular thrombosis developed in 4 of our pediatric recipients. Sheldon et al reported no renovascular thrombosis in the small num­ber of living donor transplants. [2] They specu­lated that kidney allografts from live donors may have less vascular resistance and provide better graft perfusion than deceased grafts. They also mentioned that the risk of deceased allograft thrombosis in young recipients is high, necessitating aggressive preventive mea­sures. They strongly recommended the use of living related donors in young recipients; all our patients received kidneys from living rela­ted donors.

In the Shokeir series, [15] the type of primary urinary continuity was the only factor that affectted the incidence of surgical complica­tions on multivariate analysis, with the best results achieved with the use of the extravesi­cal Lich-Gregoir technique. He observed a high complication rate with the uretero-ureteral anas­tomosis. This observation is different from a recent report on a large number of children with uretero-ureteral anastomosis by Lapointe et al who concluded that uretero-ureteral anas­tomosis is a safe and effective technique for pediatric renal transplantation with a low com­plication rate (8.4%). [13] This difference could be attributed to the fact that the vast majority of the patients in the Lapointe [13] series (144 of 166) received kidneys from deceased donors, while all of Shokeir [15] patients received live do­nor transplants. Several authors reported that the incidence of urological complications is more common with living donor transplants in comparison with deceased grafts because of the different technique of kidney retrieval. Another reason for the difference in the results is the limited number of our patients who were subjected to uretero-ureteral anastomosis in comparison to the series of Lapointe et al. [13]

Although rejection has been implicated as a possible mechanism in the development of ureteral leaks, analysis of the data in our study and in others [39],[40],[41] failed to confirm this view. Moreover, there is no evidence that multiple renal arteries are associated with an increased risk to the ureteral complications, as suggested by Hricko et al. [42] Finally, the incidence of ure­teral complications did not differ in recipients receiving cyclosporine compared with those given conventional immunotherapy. This fin­ding is not consistent with the speculation that unwanted vasoactivity associated with cyclos­porine could be associated with increased ure­teral problems.

We conclude that kidney transplantation in children is a viable treatment option for termi­nal kidney disease presenting success and sur­gical complication rate similar to kidney trans­plantation in adults. Surgical complications in pediatric and adolescent renal transplant reci­pients can be minimized if basic principles of careful transplant techniques are used. Prompt identification and treatment of any complica­tion are critical to graft and patient survival.

 
   References Top

1.Valdes R, Munoz R, Bracho E, Gordillo G, Velazquez L, Nieto J. Surgical complications of renal transplantation in malnourished children. Transplant Proc 1994;26:50-1  Back to cited text no. 1      
2.Sheldon CA, Churchill BM, Khoury AE, Mc­Lorie GA. Complications of surgical signifi­cance in pediatric renal transplantation. J Pediatr Surg 1992;27:485-490.  Back to cited text no. 2      
3.Tanabe K, Takahashi K, Kawaguchi H, Ito K, Yamazaki Y, Toma H. Surgical complications of pediatric kidney transplantation: A single center experience with the extra-peritoneal technique. J Urol 1998;16:1212-5.  Back to cited text no. 3      
4.Satterthwaite R, Aswad S, Sunga V, et al. Out­come of en bloc and single kidney transplan­tation from very young cadaveric donors. Transplantation 1997;63:1405-10.  Back to cited text no. 4  [PUBMED]    
5.Chantler C, Carter JE, Bewick M, et al. 10 years' experience with regular haemodialysis and renal transplantation. Arch Dis Child 1980; 55:435-45.  Back to cited text no. 5  [PUBMED]    
6.Zaontz MR, Hatch DA, Firlit CF. Urological complications in pediatric renal transplantation: Management and prevention. J Urol 1988;140:1123-8.  Back to cited text no. 6  [PUBMED]    
7.Weibull H, Gabel H, Fjeldborg O, et al. Renal transplantation in Nordic children. Transplant Proc 1987;19:1521-2.  Back to cited text no. 7      
8.Rigg KM, Proud G, Taylor RM. Urological complications following renal transplantation. A study of 1016 consecutive transplants from a single centre. Transplant Int 1994;7(2):120-6.  Back to cited text no. 8      
9.Cicco A, el Ghoneimi A, Baudouin V, et al. Surgical aspects of renal transplantation in children .Ann Urol 1998;32:247-52.  Back to cited text no. 9      
10.Lashley DB, Barry JM, Demattos AM, et al. Kidney transplantation in children: A single center experience. J Urol 1999;161:1920-5.  Back to cited text no. 10  [PUBMED]    
11.Koo HP, Bunchman TE, Flynn JT, Punch JD, Schwartz AC, Bloom DA. Renal transplanta­tion in children with severe lower urinary tract dysfunction. J Urol 1999;161(1):240-5.  Back to cited text no. 11      
12.Nuininga JE, Feitz WF, van Dael KC, et al. Urological complications in pediatric renal transplantation. Eur Urol 2001;39:598-602.  Back to cited text no. 12  [PUBMED]    
13.Lapointe SP, Charbit M ,Jan D, Lortat-Jacob S, et al. Urological complications after renal trans­plantation using ureteroureteral anastomosis in children. J Urol 2001;166:1046-8  Back to cited text no. 13  [PUBMED]    
14.Bouhafs A, Fassi-Fehri H, Ranchin B, et al. Surgical aspects of kidney transplantation in children (study of 148 cases). Ann Urol 2002; 36:301-9.  Back to cited text no. 14      
15.Shokeir AA, Osman Y, Ali-El-Dein B, et al. Surgical complications in live-donor pediatric and adolescent renal transplantation: Study of risk factors. Pediatr Transplant 2005;9:33-8.  Back to cited text no. 15  [PUBMED]    
16.Irtan S, Maisin A, Jacqz-Aigrain E, et al. Re­trospective analysis of surgical complications of 203 Pediatric renal transplants. Arch Pediatr 2008;15:894.  Back to cited text no. 16      
17.Shah SA, Ranka P, Dodiya S, et al. Calyceal­cutaneous fistula: An unusual complication in a series of 1020 renal transplantations. Indian J Urol 2003;20:67-8  Back to cited text no. 17    Medknow Journal  
18.Gutierrez-Calzada JL, Ramos-Titos J, Gonzalez­Bonilla JA, Garcia-Vaquero AS, Martin-Morales A, Burgos-Rodriquez R. Calyceal fistula forma­tion following renal transplantation: Manage­ment with partial nephrectomy and ureteral re­placement. J Urol 1995;153:612-4.  Back to cited text no. 18      
19.Ranchin B, Chapuis F, Dawhara M, et al. Vesico­ureteral reflux after kidney transplantation in children. Nephrol Dial Transplant 2000;15: 1852-8.  Back to cited text no. 19  [PUBMED]    
20.Hanevold CD, Kaiser BA, Palmer JA, Polinsky MS, Baluarte HJ. Vesicoureteral reflux and urinary tract infections in renal transplant reci­pients. Am J Dis Child 1987;141:982-4.  Back to cited text no. 20      
21.Dunn SP, Vinocur CD, Hanevold C, Wagner CW, Weintraub WH. Pyelonephritis following pediatric renal transplant: Increased incidence with vesicoureteral reflux. J Pediatr Surg 1987; 22:1095-9.  Back to cited text no. 21  [PUBMED]    
22.Fontana I, Ginevri F, Arcuri V, et al. Vesico­ureteral reflux in pediatric kidney transplants: Clinical relevance to graft and patient out­come. Pediatr Transplant 1999;3:206-9.  Back to cited text no. 22  [PUBMED]    
23.Cuvelier R, Pirson Y, Alexander GP, Van ypersele de Strihou C. Late urinary tract infec­tion after transplantation: Prevalence, predis­position and morbidity. Nephron 1985;40:76-8.  Back to cited text no. 23      
24.Mathew TH, Kincaid-Smith P, Vikraman P. Risks of vesicoureteric reflux in the trans­planted kidney. N Engl J Med 1977;297:414-8.  Back to cited text no. 24  [PUBMED]    
25.Waltke EA, Adams MB, Kauffman HM, Sampson D, Hodgson NB, Lawson RK. Prospective ran­domized comparison of urologic complications in end-to-side versus Politano-Leadbetter ure­teroneocystostomy in 131 human cadaver renal transplants. J Urol 1982;128:1170-2.  Back to cited text no. 25      
26.Cuvelier R, Pirson Y, Alexander GP, Van ypersele de Strihou C. Late urinary tract infec­tion after transplantation: Prevalence, predis­position and morbidity. Nephron 1985;40:76-8.  Back to cited text no. 26      
27.Mastrosimone S, Pignata G, Maresca MC, et al. Clinical significance of vesicoureteral reflux after kidney transplantation. Clin Nephrol 1993;40:38-45.  Back to cited text no. 27  [PUBMED]    
28.Mathew TH, Kincaid-Smith P, Vikraman P. Risks of vesicoureteric reflux in the trans­planted kidney. N Engl J Med 1977;297:414-8.  Back to cited text no. 28  [PUBMED]    
29.Part V, Horcichova M, Matousovic K, Hatala M, Liska M. Urinary tract infection in renal trans­plant patients. Infection 1985;13:207-12.  Back to cited text no. 29      
30.Boostma M, Kootte AM, Van Bockel JH, Obermann WR, Paul LC. The clinical signifi­cance of vesicoureteral reflux into transplanted kidneys. Clin Transplant 1987;1:311-5.  Back to cited text no. 30      
31.Grunberger T, Gnant M, Sautner T, et al. Impact of vesicoureteral reflux on graft survival in renal transplantation. Transplant Proc 1993;25: 1058-9.  Back to cited text no. 31      
32.Vianello A, Pignata G, Caldato C, et al. Vesico­ureteral reflux after kidney transplantation: Clinical significance in the medium to long term. Clin Nephrol 1997;47:356-61.  Back to cited text no. 32  [PUBMED]    
33.Molina G, Feitosa LC, Martin X, et al. Incidence of vesicoureteral reflux after allograft renal transplantation. Transplant Proc 1994;26:292.  Back to cited text no. 33  [PUBMED]    
34.French CG, Acott PD, Crocker JF, Bitter­Suermann H, Lawen JG. Extravesical urete­roneocystostomy with and without internalized ureteric stents in pediatric renal transplan­tation. Pediatr Transplant 2001;5:21-6.  Back to cited text no. 34  [PUBMED]    
35.Fontana I, Ginevri F, Arcuri V, et al. Vesico­ureteral reflux in pediatric kidney transplants: Clinical relevance to graft and patient outcome. Pediatr Transplant 1999;3:206-9.  Back to cited text no. 35  [PUBMED]    
36.Cloix P, Gelet A, Desmettre O, et al. Endoscopic treatment of vesicoureteric reflux in trans­planted kidneys. Br J Urol 1993;72:20-2.  Back to cited text no. 36  [PUBMED]    
37.Mallet R, Game X, Mouzin M, et al. Sympto­matic vesicoureteral reflux in kidney transplan­tation: Results of endoscopic injections of teflon and predictive factors for success. Prog Urol 2003;13:598-601.  Back to cited text no. 37  [PUBMED]    
38.Dammeier BG, Lehnhardt A, Gluer S, et al.Laparoscopic fenestration of posttransplant lymphoceles in children. J Pediatr Surg 2004; 39:1230-2.  Back to cited text no. 38      
39.Erlich RM, Smith RB. Surgical complications of renal transplantation. Urology 1977;10:43­-56.  Back to cited text no. 39      
40.Kashi SH, Lodge JP, Giles GR, Irving HC. Ureteric complications of renal transplantation. Br J Urol 1992;70:139-43.  Back to cited text no. 40  [PUBMED]    
41.Salvatierra O Jr, Olcott C 4th, Amend WJ Jr, Cockrum KC, Feduska NJ. Urological compli­cations of renal transplantation can be pre­vented or controlled. J Urol 1977;421-4.  Back to cited text no. 41      
42.Hricko GM, Birtch AC, Bennet AH, et al. Fac­tors responsible for urinary fistula in the renal transplant recipient. Ann Surg 1973;178:609­-15.  Back to cited text no. 42      

Top
Correspondence Address:
Rabih El Atat
Charles Nicolle Hospital, Service Urology 138 Boulevard 9 Avril, 1006 Tunis
Tunisia
Login to access the Email id


PMID: 20228509

Rights and Permissions


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]

This article has been cited by
1 Standard B presentation vs. contrast-enhanced ultrasound (US-CE). A comparison of usefulness of different ultrasonographic techniques in the evaluation of the echo structure and size of haematomas in post-renal transplant patients: A preliminary report
Grzelak, P. and Kurnatowska, I. and Nowicki, M. and Strzelczyk, J. and Sapieha, M. and Podgórski, M. and Marchwicka-Wasiak, M. and Stefańczyk, L.
Polish Journal of Radiology. 2012; 77(3): 14-18
[Pubmed]
2 Toward a standardized system for reporting surgical outcome of pediatric and adolescent live donor renal allotransplantation
Harraz, A.M. and Shokeir, A.A. and Soliman, S.A. and El-Hefnawy, A.S. and Kamal, M.M. and Kamal, A.I. and El-Din, A.B.S. and Ghoneim, M.A.
Journal of Urology. 2012; 187(3): 1041-1046
[Pubmed]
3 Extraperitoneal renal transplantation in small children results in a transient improvement in early graft function
Heap, S.L. and Webb, N.J.A. and Kirkman, M.A. and Roberts, D. and Riad, H.
Pediatric Transplantation. 2011; 15(4): 362-366
[Pubmed]



 

Top
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    Abstract
    Introduction
    Subjects and Methods
    Results
    Discussion
    References
    Article Figures
    Article Tables
 

 Article Access Statistics
    Viewed3656    
    Printed174    
    Emailed0    
    PDF Downloaded819    
    Comments [Add]    
    Cited by others 3    

Recommend this journal