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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 2  |  Page : 323-327
Catastrophic calciphylaxis in a patient with lupus nephritis and recent onset of end-stage renal disease

Department of Internal Medicine, Nephrology Division, King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Correspondence Address:
Fatma I Al Beladi
Department of Internal Medicine, Nephrology Division, King Abdulaziz University Hospital, Jeddah
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

PMID: 20228522

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Painful violaceous skin lesions that progress to non-healing ulceration and gangrene characterize calciphylaxis. These lesions are associated with secondary hyperparathyroidism and generally occur in patients on dialysis for more than one year. Hyperphosphatemia and hypoalbumi­nemia are the major risk factors for calciphylaxis. It is usually resistant to medical treatment al­though parathyroidectomy can help in controlling the disease. The mortality rate of calciphylaxis is very high due to uncontrollable sepsis. In our case, a young female with systemic lupus erythema­tosus (SLE) developed calciphylaxis within a short period after the onset of hemodialysis; she had a short period of hyperphosphatemia prior to dialysis. The serum phosphate was 4.24 mmol/L, cal­cium was 1.66 mmol/L, parathormone was 38 and calcium-phosphate was 7.0 mmol/L. It is likely that SLE provoked the development of calciphylaxis. The patient was treated medically but un­fortunately died secondary to sepsis.

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