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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 4  |  Page : 738-741
Membranoproliferative glomerulonephritis secondary to chronic myeloid leukemia

1 Department of Medical Oncology, M.S. Ramaiah Medical College, Bangalore, India
2 Department of General Medicine, M.S. Ramaiah Medical College, Bangalore, India
3 Department of Pathology, M.S. Ramaiah Medical College, Bangalore, India

Correspondence Address:
Murali Subramanian
Deptartment of Medical Oncology, M.S. Ramaiah Medical College, MSRIT Post, Bangalore-560054, Karnataka
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PMID: 20587884

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The nephrotic syndrome (NS) is a well documented complication of hematological malignancies. However, chronic myeloid leukemia (CML) is rarely complicated by the NS, and it occurs usually after allogenic stem cell transplantation or interferon alpha therapy for CML. The NS as a complication of untreated CML is also rare. We report a 31-year-old patient who pre­sented with features of The NS. He was diagnosed to have CML one year ago and was on irre­gular treatment with imatinib mesylate. The renal biopsy and immunofluorescence revealed mem­branoproliferative glomerulonephritis type I. The patient was retreated with imatinib mesylate and the NS resolved gradually over three months. This maybe the third case in literature of mem­branoproliferative glomerulonephritis associated with CML.

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