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| RENAL DATA FROM THE ARAB WORLD |
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| Year : 2010 |
Volume
: 21 | Issue : 4 | Page
: 772-777 |
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Brown tumors in patients with chronic renal failure and secondary hyperparathyroidism: Report of 12 cases
Lilia Ben Fatma1, Samia Barbouch2, Ben Hamida Fethi2, Ben Abdallah Imen2, Khiari Karima2, Helal Imed2, El Younsi Fethi2, Ben Moussa Fatma1, Goucha Rim2, Ben Abdallah Taieb2, Hedi Ben Maiz1, Khedher Adel2
1 Department of Nephrology, La Rabta Hospital, and Laboratory of Kidney Pathology, Tunis, Tunisia
2 Department of Nephrology and Internal Medicine, Charles Nicolle Hospital, and Laboratory of Kidney Pathology, Tunis, Tunisia
Correspondence Address:
Samia Barbouch
Department of Nephrology and Internal Medicine, Charles Nicolle Hospital, 09 Avril Avenue, Tunis
Tunisia
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PMID: 20587894 
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Brown tumors are unusual but serious complications of renal osteodystrophy. We retrospectively studied 12 patients presenting with chronic renal failure and brown tumor related to secondary hyperparathyroidism. Eleven patients were on chronic hemodialysis. The median duration between renal failure and end stage renal failure was 36 months (range: 12-190 months) and the median duration in dialysis for 11 cases: 92 months (range: 72-252 months). The bone pain was noted in all cases (100%), pathological fracture in one case (8%) and a palpable bone tumor in 10 cases (83%). Elevated serum Calcium (> 2.35 mmol/L) was noted in four cases (33%), elevated serum Phosphate (> 1.78 mmol/L) in ten cases (80%), elevated serum Alkaline Phosphate (> 290 UI/L) in all cases and intact PTH was > 300 pg/mL in all cases with a serum median rate at 1475 pg/mL (range: 682-3687 pg/L). Subtotal parathyroidectomy was performed in all cases with a resultant decrease in size of brown tumors. We report here patient with CKD with unusual frequency and variable locations. This may be attributed tothe lack of the new calcium free phosphate binders and calcimimetics. |
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