Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1436 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

REVIEW ARTICLE Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 6  |  Page : 1030-1037
New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients

1 Department of Nephrology, University Hospital, INF 162, Heidelberg, Germany
2 Department of Immunology, University of Heidelberg, INF 400, Heidelberg, Germany

Correspondence Address:
Claudia Sommerer
Department of Nephrology, University of Heidelberg , Im Neuenheimer Feld 162 D-69120 Heidelberg
Login to access the Email id

PMID: 21060169

Rights and Permissions

A maximum of efficacy with a minimum of toxicity is the ultimate goal of immuno­suppressive therapy. Calcineurin inhibitors are widely used as immunosuppressive drugs, and there is still a discussion about the optimal blood levels of cyclosporine A (CsA) and tacrolimus (Tac), balancing safety and efficacy. Monitoring of calcineurin inhibitor therapy is usually per­formed by blood trough levels, pharmacokinetics such as measurement of two-hour peak levels, or by various areas under the curve assessments (AUC, 4 to 12 hours). All these mentioned phar­macokinetic measurements cannot predict the individual biological effects of the immuno­suppressive drug. Several approaches have been undertaken to measure immunosuppression by calcineurin inhibitors. In this manuscript, general and specific immune monitoring strategies of calcineurin inhibitors and their clinical benefits are discussed.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1036    
    Comments [Add]    
    Cited by others 3    

Recommend this journal