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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 1  |  Page : 112-115
Drug interaction between rifampicin and sirolimus in transplant patients

Transplant Unit, Department of Surgery and Medicine and the Medical Research Council Liver Research Centre, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

Correspondence Address:
Delawir Kahn
Department of Surgery, Medical School Observatory, 7925, Cape Town
South Africa
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PMID: 21196624

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We report two cases of drug interaction between rifampicin and sirolimus in renal trans­plant patients who were diagnosed with tuberculosis after transplantation and induction of immuno­suppressive therapy with sirolimus. The dosage of sirolimus had to be increased, in one case up to six-fold and in the second case up to five-fold, to maintain serum levels after starting the rifampicin. The two patients tolerated the treatment well, with no signs of tuberculosis and good renal function.

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