|
| ORIGINAL ARTICLE |
 |
|
|
| Year : 2011 |
Volume
: 22 | Issue : 1 | Page
: 18-23 |
|
Allograft renal rejection and chemokine polymorphism
Y Gorgi1, I Sfar1, S Jendoubi-Ayed1, M Makhlouf1, T Ben Rhomdhane1, R Bardi1, H Aouadi1, T Ben Abdallah1, E Abderrahim2, K Ayed1
1 Research Laboratory of Transplantation Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis, Tunisia
2 Department of Nephrology, Charles Nicolle Hospital, Tunis, Tunisia
Correspondence Address:
Y Gorgi
Immunology Lab, Charles Nicolle Hospital, Bd 9 Avril, 1006 Tunis
Tunisia
  | Check |
PMID: 21196609 
|
|
|
Chemokines play a major role in the process by which leukocytes are recruited from the bloodstream into the sites of inflammation. Genes for the chemokine receptors CCR5, CCR2 and MCP-1 are characterized by functional polymorphisms implicated in transplant rejection. To investigate this association, we analyzed polymorphisms of CCR5-∆32, CCR5-59029-A/G, CCR2-V64I and MCP-1 G/A (-2518) in 173 renal transplant recipients and 169 healthy blood donors. The patients were classified in two groups: Group-1 (G-1) included 33 HLA-identical recipients and Group-2 (G-2) included 140 (one or more) mismatched graft recipients. Forty-two patients had developed acute rejection episodes (ARs): seven in G-1 and 35 in G-2. Thirteen G-2 patients developed chronic allograft dysfunction (CAD). The genotypic and allelic frequencies of all polymorphisms studied did not reveal significant differences between patients and controls and among G-1 and G-2 recipients. However, a significant risk of acute renal transplant rejection was found in G-1 patients who possessed the CCR2-64I allele (odds ratio 0.24, 95% confidence interval [CI], 0.05-1.06; P = 0.035). There was no significant association of this polymorphism and CAD. In conclusion, the observed association of CCR2-64I with AR should be added to the spectrum of immunogenetic factors known to be involved in allograft renal loss. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
|
|
