Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 78 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 1  |  Page : 61-66
New indicator for prostate gland biopsy when malignancy is in question

Department of Radiology, Jordan University Hospital, Amman, Jordan

Correspondence Address:
Azmi A Haroun
Department of Radiology, Jordan University Hospital, P.O. Box 460495, 11946 Amman
Login to access the Email id

PMID: 21196614

Rights and Permissions

The aim of our study was to find out a new indicator with a higher specificity level than prostate prostate-specific antigen (PSA) in order to achieve a better selection of patients who will undergo prostate biopsy. Trans-rectal ultrasound-guided prostate biopsy was performed in 135 patients who had elevated PSA level and/or palpable nodule on digital rectal examination. The PSA level was ≤10 ng/mL in 81 patients and >10 ng/mL in 54 patients. We designed a new formula consisting of prostate volume, patient's age, and free prostate specific antigen. Its resultant was defined as prostate biopsy index and was compared with the most currently used parameters. Histology results yielded prostate gland malignancy in 40 (30%) patients. Our new index differed significantly between the malignant and the non-malignant patient categories (P = 0.01). The ROC curve analysis at different specificity and sensitivity levels (85%, 90% and 95%) and regarding the area under the curve (AUC), our new index was significantly better than the other studied parameters (P = 0.001). Additionally, the AUC in patients with a PSA level ≤10 ng/mL and bet­ween 10.1 and 20 ng/mL was 0.75 and 0.78, with a sensitivity of 91% and 83% and a specificity of 24% and 73%, respectively, at a cut-off point of 1.7. The overall sensitivity and specificity at the same point were 80% and 41%, respectively. In conclusion, the performance of our new index was superior to all other evaluated parameters. At 83% sensitivity with a cut-off point of 1.7, 63.5% of the performed biopsies could have been avoided in patients with a PSA level between 10.1 and 20 ng/mL.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded496    
    Comments [Add]    

Recommend this journal