Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1629 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

CASE REPORT Table of Contents   
Year : 2012  |  Volume : 23  |  Issue : 2  |  Page : 330-333
A case of exorbitism in association with Wegener's granulomatosis with renal involvement

1 Department of Nephrology, La Rabta Hospital, Tunis, Tunisia
2 Ophtalmology Institute, Hedi Rais, Tunis, Tunisia
3 Laboratoire de Recherche de Pathologie, Rénale LR00SP01, Tunisia

Correspondence Address:
S Beji
Department of Nephrology, La Rabta Hospital, Jabbari 1007, Tunis
Login to access the Email id

PMID: 22382229

Rights and Permissions

Wegener's granulomatosis (WG) is a necrotizing granulomatous vasculitis invol­ving the nose, paranasal sinuses, lungs, and kidneys. Ocular involvement can occur in about 50% of cases. There are very few reports of WG with orbital inflammation and exorbitism. We report a case of a female patient who presented with exorbitism related to orbital inflammation secondary to WG, with renal involvement. A 29-year-old woman with a previous history of recurrent pan-sinusitis presented with bilateral exophthalmos and renal failure with rapidly progressive glo-merulonephritis. Computed tomography showed extensive bilateral soft tissue in the retro-orbital area. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies and renal biopsy revealed pauci immune crescentic glomerulonephritis. The patient was treated with corticosteroids and pulses of cyclophosphamide followed by azathioprine and trimethoprim-sulfamethoxazole. After a follow-up of 10 months, the renal outcome was favorable with improvement of renal function but there was persistence of exorbitism and loss of visual function. Our case suggests that WG should be considered in the differential diagnosis of persistent bila­teral exophthalmos. Prompt recognition of this early manifestation is important for the institution of early treatment.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded425    
    Comments [Add]    

Recommend this journal