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RENAL DATA FROM ASIA-AFRICA |
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| Year : 2012 | Volume
: 23
| Issue : 3 | Page : 619-628 |
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| Spectrum of community-acquired acute kidney injury in India: A retrospective study |
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Anupma Kaul1, Raj Kumar Sharma1, Rama Tripathi1, Krishnaswamy Jai Suresh1, Sanjay Bhatt2, Narayan Prasad1
1 Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttarpradesh, India
2 Department of Surgery, Era's Lucknow Medical College, Lucknow, Uttarpradesh, India
Click here for correspondence address and email
| Date of Web Publication | 7-May-2012 |
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 Abstract | | |
An understanding of the epidemiology of community-acquired acute kidney injury (CAAKI) is necessary to establish its overall burden and plan potential preventive strategies. This study was done in an urban tertiary care center in northern India with the aim to identify the etiology and outcomes as well as the factors associated with in-hospital mortality of CAAKI patients. A five year retrospective analysis of all patients with CAAKI admitted to the Nephrology Department from January 2005 to December 2009 was done. From 5499 consecutive patients, 240 patients (2.5%), with a mean age of 39.8 ± 14.48 years, were diagnosed to have CAAKI as per our specified criteria. The most common cause of CAAKI was medical (77.5%), followed by obstetrical (14.2%) and surgical (8.3%) causes. Among the medical causes, acute diarrheal disease was the most common cause (29%), followed by malaria (18.8%) and sepsis (13.9%). Sepsis had the highest in-hospital mortality (46%). Nephrolithiasis was the most common surgical cause. Puerperal sepsis (44.1%), pre-eclampsia (23.5%), intrauterine death (11.8%), antenatal hemorrhage (11.8%) and post-partal hemorrhage (8.8%) were the obstetric causes of CAAKI. Among 45 patients who underwent a renal biopsy, acute tubulointerstitial nephritis (33.3%) was the most common, followed by acute tubular necrosis (22.2%), glomerulonephritis (17.7%), thrombotic microangiopathy (17.7%) and acute cortical necrosis (8.89%). Of the 83% patients who underwent dialytic therapy, 44.5% underwent hemodialysis, 22.5% continuous veno-venous hemodiafiltration, 21.6% sustained low efficiency dialysis and 11.4% peritoneal dialysis. The overall in-hospital mortality among patients with CAAKI was 26.20%. CAAKI remains a common problem affecting nearly 2.5% of patients attending nephrology units.
How to cite this article:
Kaul A, Sharma RK, Tripathi R, Suresh KJ, Bhatt S, Prasad N. Spectrum of community-acquired acute kidney injury in India: A retrospective study. Saudi J Kidney Dis Transpl 2012;23:619-28 |
How to cite this URL:
Kaul A, Sharma RK, Tripathi R, Suresh KJ, Bhatt S, Prasad N. Spectrum of community-acquired acute kidney injury in India: A retrospective study. Saudi J Kidney Dis Transpl [serial online] 2012 [cited 2022 Jan 28];23:619-28. Available from: https://www.sjkdt.org/text.asp?2012/23/3/619/95859 |
| Introduction | |  |
In the past few decades, nephrology care in India has seen impressive advancements. [1] Despite improvements in preventive and diagnostic facilities, community acquired acute kidney injury (CAAKI) still remains a major reason for admissions to nephrology units. Acute kidney injury (AKI) is the most common renal emergency in India, and as many as 1.5% of hospital admissions are referred to nephrology service for acute renal failure. [2],[3],[4]
The etiology of CAAKI in tropics is different from that seen in other countries. Trauma, surgery and sepsis contribute to a majority of the cases of AKI in developed countries. [5] In contrast, AKI in tropical countries occur in the younger age group and usually follows infections and obstetric complications. Poor hygiene, warm climate, low socioeconomic status, widespread availability of over-the-counter drugs and high incidence of infections like malaria and leptospirosis contribute to the varied etiology of CAAKI seen in India. [6] It is important to understand that epidemiology of CAAKI will be influenced by the changes in the epidemiology of infections causing it. For example, malarial AKI, which was seen predominantly in Plasmodium falciparum infections, is being increasingly seen in Plasmodium vivax infections. [7],[8] Sethi et al have demonstrated an increasing incidence of leptospirosis in northern India from 11.5% in 2004 to 20.5% in 2008. Sixty percent of the 86 cases included in their study had AKI. [9]
A significant trend changes in the epidemiology of CAAKI are being observed in the past few years. Incidence of diarrheal disease, intravascular hemolysis, copper sulfate poisoning and obstetric CAAKI are decreasing. [10],[11] A single-center study from eastern India has shown a reduction in the incidence of acute cortical necrosis from 6.7% in 1994 to 1.6% in 2005. [12] In contrast, there is an increase in the incidence of surgical and sepsis-related AKI. [13],[14]
These dynamic trend changes mandate the need for frequent epidemiological studies to devise preventive and therapeutic strategies. The aim of the present study is to identify the etiology and outcomes of CAAKI and analyze the risk factors for in-hospital mortality in patients admitted with CAAKI.
| Materials and Methods | | |
We conducted a retrospective analysis of all patients who were admitted to the Nephrology department from January 2005 to December 2009. The facility is a tertiary care referral center in Northern India catering to the states of Uttarpradesh, Bihar, Madyapradesh and Jharkhand. The majority of the population belongs to Indo-Aryan subraces in the low-and middle-socioeconomic status. Patient data were recovered from the computerized hospital information system. All patients with the diagnosis of "acute renal failure" or "acute kidney injury" as their hospital admission diagnosis were included in the study. The term AKI is followed in this article to represent both "acute renal failure" and "acute kidney injury." Community-acquired AKI was defined as a serum creatinine of ≥2 mg/dL at the time of admission in a patient with normal-sized kidneys and prior normal renal function. All records of patient's history, physical examination, laboratory investigations and discharge reports were examined by two nephrologists. A clinical and histopathological diagnosis was made after scrutinizing all the details. Patients who had diabetes mellitus, pre-existing renal insufficiency or referred following a hospital-acquired renal insufficiency were excluded from the study. A total of 339 case records were examined and, of these, 240 patients who satisfied the inclusion criteria were analyzed. Patients who did not have their previous renal function records or prior history of renal disease were presumed to have normal renal function in the past. The first serum creatinine obtained after admission to the hospital was taken as baseline value. Oliguria was defined as urine output <400 mL/24 h. Decreased renal perfusion was identified by one or more of: (a) decrease in blood pressure to less than 90/60 mmHg, (b) evidence of congestive heart failure, (c) signs of volume depletion or (d) improvement with restoration of blood flow. Drugs were identified as cause of AKI when there was a temporal relationship to administration of the drug in the absence of other pathogenetic mechanisms. Sepsis was defined as two or more of the following as a result of proven or suspected infection: (a) temperature >38°C or <36°C, (b) heart rate >90/min, (c) respiratory rate >24/min and (d) white blood count >12,000/μL, <4000/μL or >10% band forms. Obstruction was considered to be responsible if there was evidence of obstruction on imaging studies and improvement in renal function with relief of obstruction. Hepato-renal syndrome was the cause of renal failure if a patient with liver failure has renal failure with urine sodium less than 15 meq/L in the absence of other identifiable cause of renal failure. Acute tubular necrosis was considered when renal functions did not improve after correction of possible pre-renal causes and when hepato-renal syndrome and vascular, interstitial, glomerular and obstructive etiologies were ruled out. Acute glomerulonephritis was considered in a case with histological confirmation except for acute post-infectious state with clinical and biochemical markers substantiating the diagnosis. Acute tubulointerstitial nephritis was considered in state of high grade of clinical suspicion or a histological demonstration. Patients were evaluated on the following outcomes: complete recovery, partial recovery not requiring renal replacement therapy (RRT), discharged on RRT or in-hospital mortality.
| Statistical Analysis | | |
Values were expressed as mean ± standard deviation. Univariate analysis to identify risk factors was performed using chi-square test or Fisher's exact test for discrete variables and Student's "t " test for continuous variables. Thirty-six variables including age, need for Intensive Care Unit care, hypotension at admission, jaundice, oliguria, icterus and encephalopathy were compared in survivors and non-survivors. Statistical analysis was done with SPSS 15 software for windows. A P-value less than 0.05 was considered significant.
| Results | | |
Of the 5499 consecutive patients admitted during a five-year period between January 2005 and December 2009, 240 patients (2.5%) were diagnosed to have CAAKI. The mean age of the population was 39.8 ± 14.48 years. One hundred and forty-one (58.9%) were males while 99 (41.2%) patients of the 240 were females. The mean age of males was 39.23 ± 14.64 years and mean age among females was 40.63 ± 14.28 years.
The most common cause of CAAKI was medical (77.5%), followed by obstetrical (14.2%) and surgical causes (8.3%). Among the medical causes, acute diarrheal disease was the most common cause (29%), followed by malaria and sepsis [Table 1]. Fifteen percent (36 episodes) of the CAAKI followed diarrheal episodes. Eleven had positive bacterial stool analysis, which included Salmonella More Details (four), Shigella (three), E. coli (two) and V. cholerae (two). Eighteen patients required emergency dialytic therapy at the time of admission. Severe metabolic acidosis (six patients), hyperkalemia (four patients) and volume overload (four patients) were the most common indications for emergency dialysis.
Puerperal sepsis was the most common cause of obstetric CAAKI (44.1%), followed by pre-eclampsia (23.5%), intrauterine death (11.8%), antenatal hemorrhage (11.8%) and post-partum hemorrhage (8.8%). Among the surgical causes of CAAKI, nephrolithisis was the most common etiology presenting with obstruction and acute renal failure. Twelve of the 20 patients with surgical CAAKI had nephrolithiasis as the cause of obstruction. In four patients, carcinoma cervix was the cause of obstructive AKI.
The "histological diagnosis" of all 240 patients was analyzed. Forty-five patients underwent renal biopsy during their hospital stay [Table 2]. The most common indication for renal biopsy in our population was persistent renal failure of more than three weeks duration. Absence of an obvious cause for CAAKI and extrarenal manifestation suggestion of a systemic disease were the other common indications of renal biopsy. In those patients who did not undergo renal biopsy, a "probable" histological diagnosis was assigned based on patient's history, clinical findings, laboratory investigations and hospital course.
When the histological diagnosis (biopsy diagnosis or "probable" histological diagnosis) was analyzed, acute tubular necrosis (ATN) was the most frequent cause of CAAKI. Hypovolemia was the most common precipitating factor for ATN (54 patients). However, in those patients who underwent a renal biopsy, acute interstitial nephritis was the most common diagnosis. Drugs were the most common etiological agents of AIN, causing 14 of the 25 episodes. Analgesics (seven episodes), antibiotics (ampicillin - three, cotrimoxazole - two), acyclovir (one episode) and aminoglycoside (one episode) were the drugs causing AIN.
Thrombotic microangiopathy needs a special mention as it presents interesting diagnostic challenges in adults with AKI [Table 3]. These disorders at presentation are often misdiagnosed as sepsis, complicated malaria, HELLP syndrome or antiphospholipid antibody syndrome (APLA) syndrome. In India, complicated malaria often presents with fever, thrombocytopenia, renal failure and neurological symptoms mimicking hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Often, renal biopsy is needed to confirm the diagnosis when other laboratory parameters are equivocal. The disease needs to be identified because of its favorable response to early initiation of plasma exchange. Of the eight patients who had a diagnosis of thrombotic microangiopathy in renal biopsy, five had a clinical diagnosis of HUS, two had a diagnosis of TTP and one patient had primary APLA syndrome. Eighteen percent had icterus, 23.7% had encephalopathy and 65% were oliguric at presentation. 14.6% patients required less than 14 days of hospital stay. The mean duration of hospital stay was 44.8 ± 29.3 days. 32.9% (79 patients) needed mechanical ventilation during their hospital stay. Dialysis was indicated in 83%. 44.5% (89 patients) underwent conventional hemodialysis, 22.5% (45 patients) underwent continuous venovenous hemodiafiltration (CVVHDF), 21.6% (43 patients) sustained low efficiency dialysis (SLED) while 11.4 % underwent peritoneal dialysis (PD) [Figure 1]. The vascular access used was femoral venous catheter in 39% and internal jugular access in 61% of the dialysis sessions. One hundred and six patients (44%) had complete recovery of renal function and 33 patients had partial recovery of renal function. Thirty-eight patients (15%) were discharged on long-term RRT. The overall in-hospital mortality among patients with CAAKI was 26.20% [Figure 2]. In comparison with survivors, factors associated with increased in-hospital mortality (P <0.05) are depicted in [Table 4].
| Discussion | | |
Ever since the introduction of the term "acute renal failure" by Homer W. Smith in 1951, at least 35 different definitions have been used to identify the syndrome. [15] The incidence varies from 1% to 31%, and mortality ranges from 28% to 82% depending on the definition used. [16],[17],[18] Hoste et al in a recent review on the epidemiology of AKI identified the most specific definition of AKI as an absolute increase of serum creatinine of ≥2.0 mg/dL. The same definition has been used by us to diagnose CAAKI in our patients. [19]
2.5% of the patients admitted to the nephrology department of our hospital had a diagnosis of CAAKI. The mean age of the population admitted with CAAKI was 39.8 years. Only 9.1% were more than 60 years of age. Although this may be reasoned by the shorter life expectancy in Indian population, it also implies to the occurrence of CAAKI in the younger age group as compared with developed countries. In a country like India, where access to health care insurance is limited, CAAKI in the middle-aged population creates a huge economical burden on families.
Medical causes accounted for about three-fourth of CAAKI. Diarrheal diseases, malaria and sepsis contribute to 47.9% of CAAKI. Diarrheal diseases still continue to be the most common cause of CAAKI in our population. Shigella, E. coli and Salmonella are the most common etiological agents in this region, with seasonal occurrences of V. cholerae. [20] Although the incidence of diarrheal disease-related acute renal failure has decreased from 23% in the 1960s to <10%, diarrheal diseases still continue to be a major cause of CAAKI necessitating emergency dialytic therapy. [21]
India contributes 80% of all the cases of malaria in Southeast Asia. The prevalence of AKI in malaria is less than 1%, but increases to 60% in severe infections. [22] Although falciparum infections remain the most common cause of complicated malaria, various Indian investigators have documended the increasing incidence of complicated malaria in Plasmodium vivax infections. [7],[8],[23] Twenty percent (seven out of 35) of our patients with malaria AKI had P. vivax infection; in contrast, 6.25% of malarial AKI follows P. vivax infections in southern India. This could indicate an increasing incidence of vivax malaria in our population or a rising rate of AKI in P. vivax infections.
Sepsis had the highest in-hospital mortality of 46%, which is similar to data from other Indian centers. Worldwide, the incidence of sepsis-related AKI is increasing [14] and occurrence of AKI represents an independent risk factor for in-hospital mortality in these patients. [24]
Pregnancy-related AKI comprise 9-25% of nephrology referrals in developing countries as compared with 1-2.8% in the developed world. In northern India, the incidence of obstetric AKI decreased from 22% in the 1960s to 10% in the 1980s. [10] Since then, the incidence of obstetric AKI has remained fairly constant, between 10% and 15%. However, significant improvement in maternal mortality has been achieved. Maternal mortality has decreased from 20% in the 1980s to 6.4% in the 1990s. [11] Obstetric AKI contributed to 14% of CAAKI in our population and had 36% mortality. This higher mortality may be due to the higher percentage of patients with puerperal sepsis (35%), improper delivery techniques and delayed referral.
8.3% of CAAKI was due to surgical causes. Nephrolithiasis was the most common cause. Urinary stone disease in the Indian population is different from that in the Western countries, with a larger percentage of patients having calcium oxalate stones. Previous studies in our center have found calcium oxalate monohydrate as the major component of stones, with hyperoxaluria and hypocitraturia being the most common urinary abnormalities. [25] Dietary factors, inherited metabolic disorders and fluid losses contribute to the increased incidence of nephrolithiasis in the Asian population. [6] Four of the 20 patients with surgical AKI had obstructive uropathy due to carcinoma cervix presenting as AKI. Such complications are not uncommon in the Indian population, and indicate the need for improved screening covering the widest possible population and also regular follow-up of women with pre-cancerous lesions. [26],[27]
In southern India, snake bite causes 7.8% of AKI and copper sulfate poisoning contributes to 4.7% of AKI. [13] In contrast, none of our patients with CAAKI had snake bite or copper sulfate poisoning. Another significant trend is the increasing incidence of leptospirosis-related AKI in north India. 6.25% of the AKI in our population was due to leptospirosis, which is similar to data from southern India. Histology helps in diagnosis, predicting disease course and outcomes. Around one-fifth of our patients with CAAKI underwent a renal biopsy, 33.3% had AIN, followed by ATN -22.2%. In comparison, Liano et al biopsied 6.15% of patients with AKI observed AIN in 8.6%, ATN in 8.6% and glomerular diseases in 39%. [28] The higher percentage of AIN seen in our study may be due to easy availability of over-the-counter medications and frequent use of drugs from alternate systems of medicine. In AKI, the most useful role of kidney biopsy is in early detection of glomerular diseases, as it helps to plan therapy and to estimate prognosis. The percentage of glomerular disease and thrombotic microangiopathy were equal in our series. This is because patients with classical post-infectious glomerulonephritis were not biopsied. TTP and HUS are disorders characterized by fever, Coomb's-negative microangiopathic hemolytic anemia, thrombocytopenia and systemic ischemia and multiple organ failure. [29]-[32] In Asia, HUS is responsible for 25-55% of pediatric AKIs. [33],[34],[35] Although E. coli O157:H7 is the most common cause in many parts of the world, Shigella is the primary etiological agent in the Indian population and has poor outcomes with a mortality rate of 60%. [6]
Literature on the choice of dialytic modality is conflicting and no study has conclusively demonstrated the appropriate type and dose of RRT in AKI. [36] In India, use of continuous renal replacement therapy (CRRT) as a dialytic modality is increasing with the availability of advanced equipments and bicarbonate replacement solutions. When the choice of dialytic modality in our center was analyzed, decreasing anticoagulation, reducing cost and improving patient mobility were the major reasons to choose SLED over CRRT. Continuous therapies were preferred in those who are hemodynamically unstable, patients requiring large volume infusions and septic shock.
Acute PD was used in 11% of the patients. Although hemodialysis has become the preferred dialysis modality in many centers, PD, because of easy availability and cost benefits, remains the major dialytic modality in many Indian hospitals. Hayat et al [37] reported a survival rate of 90% in adult AKI patients of northern India who underwent PD. Gabriel et al [38] have recently suggested that PD was associated with more rapid renal recovery in AKI. PD can also be used as a "bridge," thereby avoiding the use of central venous catheters, which can be associated with infectious complications such as bacterial endocarditis. [39]
The overall in-hospital mortality among patients with CAAKI was 26.2%. Sepsis had the highest in-hospital mortality. Indian studies on CAAKI report a mortality of 16-26%. [40] As compared with hospital-acquired AKI, the lower mortality rate in CAAKI is probably due to the higher percentage of diarrheal disease and younger age group of our population. Instead, this could also imply a trend toward better survival in AKI.
Fifteen percent of the patients were discharged on RRT. Among survivors of AKI, at long-term follow-up (1-10 years), approximately 12.5% are dialysis dependent and 19-31% have chronic kidney disease. [41] Even in patients who do not require dialysis, AKI is associated with increased long-term mortality risk, independent of their residual kidney function. [42]
When survivors and non-survivors were compared, need for assisted ventilation, encephalopathy at presentation, hypotension at presentation, oliguria at presentation, hemoglobin levels <10 gm/dL at admission, serum creatinine >4 mg/dL, serum albumin <3.5 mg/dL and coexisting liver disease were associated with increased in-hospital mortality. In comparison, Liano et al [28] in the largest epidemiological study of 748 acute renal failure patients identified presence of oliguria, sustained hypotension, assisted respiration, jaundice, sedation or coma as risk factors of mortality.
In conclusion, CAAKI remains a common problem affecting 2.5% of patients in nephrology unit. Infections and obstetric causes lead to majority of CAAKI episodes. Hemodialysis is the preferred treatment modality. In India, use of SLED and CRRT in the management of CAAKI is increasing.
| Acknowledgment | | |
The authors thank Dr. Mandal SN. PhD, for assistance in preparing the manuscript.
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Correspondence Address:
Anupma Kaul
Assistant Professor, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttarpradesh
India
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[Figure 1], [Figure 2]
[Table 1], [Table 2], [Table 3], [Table 4] |
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| This article has been cited by | | 1 |
Community-acquired acute kidney injury in tropical countries |
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| Jha, V. and Parameswaran, S. | | Nature Reviews Nephrology. 2013; 9(5): 278-290 | | [Pubmed] | |
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