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| ORIGINAL ARTICLE |
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| Year : 2013 |
Volume
: 24 | Issue : 6 | Page
: 1165-1169 |
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Predictors of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism
M Hamouda1, N Ben Dhia1, S Aloui1, S El Mhamedi2, H Skhiri1, M Elmay1
1 Department of Nephrology, Fattouma Bourguiba Hospital; Department of Epidemiology, University Hospital of Monastir University Faculty of Medicine, Monastir, Tunisia
2 Department of Preventive Medicine; Department of Epidemiology, University Hospital of Monastir University Faculty of Medicine, Monastir, Tunisia
Correspondence Address:
M Hamouda
Department of Nephrology, Fattouma Bourguiba Hospital, Monastir, 5000
Tunisia
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DOI: 10.4103/1319-2442.121273 PMID: 24231478 
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We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism. The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing para-thyroidectomy: the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol/L or less, and the normocalcemia group (48 patients), with post-operative serum Ca levels higher than 2 mmol/L. By using multivariate stepwise logistic regression analysis, high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcemia with an adjusted odds ratio (aOR) of 3.01, followed by hypo-albuminemia (aOR = 2.72), younger age (aOR = 2.56), and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28). We conclude that among patients with secondary hyperparathyroidism, age, levels of pre-operative serum Ca, ALP and albumin correlate positively with the development of early post-operative hypocalcemia. Patients with one of these factors should be monitored more closely in the early post-parathyroidectomy period. |
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