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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 3  |  Page : 634-637
ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane

1 Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
2 Department of Pathology, The Methodist Hospital, Houston, Texas, USA

Correspondence Address:
Dr. Sreedhar Mandayam
Department of Medicine, Baylor College of Medicine, Houston, TX 77030
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DOI: 10.4103/1319-2442.132221

PMID: 24821165

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides is an important cause of rapidly progressive glomerulonephritides (RPGN), and they are classically described as pauci-immune diseases as evidenced by the absence of immune deposits on immunofluoresence microscopy of the kidney biopsy. We report two patients with RPGN, pulmonary-renal syndrome, positive ANCA serology and linear Immunoglobulin G (IgG) staining on glomerular basement membrane in the absence of detectable anti-glomerular basement membrane (anti-GBM) antibodies in the serum.

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