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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 4  |  Page : 769-773
Association of serum fetuin-A and biochemical parameters in hemodialysis patients


1 Clinical Research Development Unit, 5-Azar Medical-Educational Center, Golestan University of Medical Sciences, Gorgan, Iran
2 Department of Internal Medicine, Alborz University of Medical Sciences, Karaj, Iran
3 Department of Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4 Department of Epidemiology, Tehran University of Medical Sciences, Tehran, Iran
5 Liver and Pancreatobiliary Disease Research Center, Digestive Research Institute, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Medical Laboratory Sciences, Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran

Correspondence Address:
Hamid Reza Joshaghani
Department of Medical Laboratory Sciences, School of Paramedicine, Building of Falsafi, Hircan Boulevard, Gorgan
Iran
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DOI: 10.4103/1319-2442.134993

PMID: 24969186

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Fetuin-A, a hepatic glycoprotein present in the circulation, is a potential inhibitor for systemic calcification. The main aim of this study was to evaluate the association between fetuin-A and other biochemical parameters as facilitator factors for developing atherosclerosis in hemodialysis (HD) patients. This case-control study was conducted on 44 HD patients undergoing treatment in 2012. Parathormone (i-PTH) and fetuin levels were performed by the enzyme-linked immunosorbent assay method, high-sensitivity C-reactive protein (hs-CRP) by chemiluminescence, low-density lipoprotein by direct enzymatic, calcium and albumin by colorimetric and phosphorous by ultraviolet (UV) methods. Chi-square was used for evaluating the association between variables and t-test was used for comparing the mean of the quantitative variables for the two groups. SPSS-16 software was used for data analysis and P-value less than 5% was considered as significant. Mean of serum fetuin level was 23.25 ± 4.90 ng/mL in HD patients and 32.92 ± 5.21 in the control group. Median of hs-CRP was 2.45 mg/dL in the patients and 1.00 mg/dL in the control group and i-PTH was 74.3 pg/mL in the patients and 7.30 pg/mL in the control group. The calcium-phosphorous product was 46.77 ± 14.22 mg/dL in the patient and 31.73 ± 6.48 mg/dL in the control group. A reverse significant association was found between fetuin-A and hs-CRP in this study. In this study, serum fetuin-A level in HD patients was lower than controls. Therefore, a low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition.


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