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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2014  |  Volume : 25  |  Issue : 4  |  Page : 864-868
Low-dose corticosteroid and gallium-67 scintigraphy and acute interstitial nephritis


Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan

Correspondence Address:
Tetsu Akimoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498
Japan
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DOI: 10.4103/1319-2442.135184

PMID: 24969203

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We describe a 19-year-old male who developed diclofenac-induced acute inters­titial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and promptly recovered after initiation of low-dose prednisolone (0.5 mg/kg/day). There are no established criteria for the administration of corticosteroids in the treatment of drug-induced AIN. Moreover, no clear recommendations regarding the optimal dose and duration of steroid administration in the treatment for drug-induced AIN has been established. In addition, we discuss the clinical benefit of steroid treatment and the diagnostic impact of Ga scanning on the management of drug-induced AIN.


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