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Saudi Journal of Kidney Diseases and Transplantation
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RENAL DATA FROM ASIA - AFRICA Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 4  |  Page : 912-917
Outcome of sepsis-associated acute kidney injury in an intensive care unit: An experience from a tertiary care center of central Nepal


1 Department of Nephrology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal
2 Department of Cardiology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal
3 Department of Neurology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal

Correspondence Address:
Madhav Ghimire
Department of Nephrology, College of Medical Sciences-Teaching Hospital, Bharatpur
Nepal
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DOI: 10.4103/1319-2442.135229

PMID: 24969216

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Acute kidney injury (AKI) is a common and major complication of sepsis. Sepsis-induced AKI is associated with higher morbidity and mortality. A prospective study was designed to include all the patients with a provisional diagnosis of sepsis with AKI admitted in our inten­sive care unit from August 2009 to September 2010. Detailed demographic data including various clinical parameters, co-morbidities, investigations, complications and outcome were entered in a designated proforma and were analyzed. A total of 53 subjects with the provisional diagnosis of sepsis with AKI were included in the study. The majority of patients (60.37%) were female. The mean age of the study population was 45.84 ± 20.5 years. Forty-nine percent of the subjects were <45 years old and 26.4% patients were >65 years. Among the co-morbid conditions, 9.4% subjects had diabetes mellitus type 2. Among the primary causes of AKI, 72% of the cases were due to medical causes, in which pneumonia was the major cause, and 28% were due to surgical causes, in which cholecystitis was the major cause. 47.1% cases expired, 11.3% subjects left against medical advice and 41.5% cases had favorable outcome. Among the expired cases, 20.7% subjects expired within 24 h; for others, the median hospital stay was four days. This prospective study showed that the major causes of AKI were medical illness and pneumonia. Mortality in sepsis-induced AKI is significantly high. This highlights the importance of prevention of AKI in sepsis by early and renal-friendly aggressive treatment of sepsis and the need for improvement in the management of such AKI cases.


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