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Saudi Journal of Kidney Diseases and Transplantation
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BRIEF COMMUNICATION Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 5  |  Page : 1026-1029
Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis

1 Nuclear Medicine Department, Pasteur Institute of Tunis, Tunis, Tunisia
2 Nephrology Department, Hedi Chaker Hospital, Sfax, Tunisia
3 National Transfusion Blood Center, Tunis, Tunisia
4 Nephrology Department, Fattouma Bourguiba Hospital, Monastir, Tunisia

Correspondence Address:
Dr. Chokri Maktouf
Nuclear Medicine Department, Pasteur Institute of Tunis, Tunis
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DOI: 10.4103/1319-2442.139905

PMID: 25193901

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Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients. While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE. The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis]. The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F/11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls. The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity. However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis. The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.

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