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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 26  |  Issue : 3  |  Page : 477-481
The effectiveness of systemic antibiotic therapy with and without ethanol-locked solution in the treatment of hemodialysis-related catheter infection

1 Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Dana Pharmaceutical Company, Dana Company, Tabriz, Iran
3 Hemodialysis Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
4 Central Laboratory, Imam Reza Hospital, Tabriz, Iran

Correspondence Address:
Dr. Hosein Mahdipur
Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz
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DOI: 10.4103/1319-2442.157315

PMID: 26022017

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Bacterial overgrowth in the inner layer of the catheter as a biofilm is highly encountered in routine medical care, and it may occur in a few days after inserting a catheter as an access in hemodialysis (HD) patients. Catheter-induced bacteremia is often due to the development of biofilms. Locking catheters with antimicrobial agents is an effective way of reducing the risk of catheter-related infection. In a controlled, randomized clinical trial, 64 chronic HD patients (32 men and 32 women with a mean age of 57.5 ± 15.6 years) were divided into case and control groups, with 32 patients in each group. The case group received systemic antibiotic and a lock of catheters with 60% ethanol and the control group received only systemic antibiotic. The results were evaluated after three weeks of treatment. The success rate of clearing infection in group A (29 patients) and group B (18 patients) was 90.6% and 56.2%, respectively (P = 0.002). We conclude that the significant difference in the success rate of clearing catheter infection in HD patients is due to the use of 60% ethanol-lock along with antibiotic therapy, and suggest this for routine use.

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