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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2015  |  Volume : 26  |  Issue : 3  |  Page : 584-588
Coexistence of sickle cell nephropathy and lupus nephritis in a Sudanese child

1 Jaffer Ibn Auf Pediatric Specialized Hospital, Khartoum, Sudan
2 Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
3 Faculty of Medical Lab Science, Alzaeim Alazhari University, Khartoum, Sudan
4 School of Medicine, Ahfad University for Women, Khartoum, Sudan

Correspondence Address:
Dr. Ahmed B Idris
Jaffer Ibn Auf Pediatric Specialized Hospital, Khartoum
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DOI: 10.4103/1319-2442.157397

PMID: 26022033

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In spite of the wide distribution of sickle cell disease (SCD) in Africa, an association with systemic lupus erythromatosis (SLE) is seldom reported. This may be due to the poor association between the two diseases or the high prevalence of missed cases. Progressive renal injury is prominent in both SCD and SLE. In this communication, we are presenting a case of an 11-year-old male who presented with sickle cell nephropathy that manifested as nephrotic syndrome with no response to conservative therapy, alongside unexplained massive hemolysis. His renal biopsy proved SLE superimposed on sickle cell nephropathy. We are stressing the importance of considering alternate disease processes in patients with SCD when symptoms change or when there is an atypical clinical course.

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