Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1292 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

ORIGINAL ARTICLE Table of Contents   
Year : 2016  |  Volume : 27  |  Issue : 4  |  Page : 677-684
Interaction between blood and dialysis membrane in hepatitis-C virus-infected patients: A comparative study


Department of Medicine, Renal Unit, Suez Canal University, Ismailia, Egypt

Correspondence Address:
Assem El-Sherif
Department of Medicine, Renal Unit, Suez Canal University, Ismailia
Egypt
Login to access the Email id


DOI: 10.4103/1319-2442.185223

PMID: 27424683

Rights and Permissions

Hepatitis-C virus (HCV) infection remains highly prevalent among hemodialysis (HD) patients, but there is a notable paucity of information on aspects of bio-incompatibility in those infected patients. This study aimed to answer the following question: In HD patients, does chronic HCV infection attenuate the acute inflammatory response that results from contact of patient's blood with the dialyzer membrane? We elected to investigate the contact response in the initial 15 min of a standardized single dialysis session in a before-after design. Thus, we compared magnitude of dialysis-induced changes in total leukocyte counts, platelet counts, and C3a levels in a cohort of HCV-infected and a cohort of non-infected dialysis patients (57 patients in each group). Distribution of gender, age groups, and hypertension was comparable in both HCV-infected and non-infected patients. Furthermore, the baseline pre-dialysis measurements of the studied biocompatibility markers showed statistically equivalent values in the two groups with the exception of a marginally lower platelet count among HCV-infected patients. After 15 min of HD, the total leukocyte count dropped by 16% in HCV-infected patients and by 21.5% in the non-infected group (P <0.01). However, in both groups of patients, all values remained within the customary warm zone of normal distribution of these cells in the general population. There was no statistically significant difference between the two groups in dialysis-induced thrombocytopenia or C3a levels. The magnitude of cell count reduction and complement activation in both the HCV-infected and non-infected groups of HD patients was modest and unlikely to symbolize any clinical relevance. A valid answer to our research question may be only distinctly obtained if novel molecular and sub-molecular biomarkers for detection of micro-inflammation are used.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2471    
    Printed15    
    Emailed0    
    PDF Downloaded283    
    Comments [Add]    

Recommend this journal